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A focus of research has been investigations on the role of cutaneous angiotensin receptors and locally synthesised angiotensin II in wound healing, in dermatoses associated with skin fibrosis and in melanoma. This review will provide an introduction into the RAS with emphasis on information relevant for the cutaneous RAS. It will discuss the role of the RAS in skin physiology, followed by a detailed review of the existing literature addressing the role of local angiotensin II and angiotensin AT<jats:sub>1<\/jats:sub> and AT<jats:sub>2<\/jats:sub> receptors in wound healing and in various skin diseases such as hypertrophic scars\/keloids, scleroderma, dystrophic epidermolysis bullosa, Dupuytren's disease, squamous cell carcinoma, melanoma and psoriasis. In a final section, the potential relevance of drugs, which interfere with the RAS, for future therapy of dermatological disorders is discussed. Collectively, research about the RAS in skin can currently be described as an area, which has gained increasing attention by basic researchers, thus resulting in a multitude of preclinical studies pointing to the potential relevance of components of the RAS as drug targets in dermatological diseases. With a few small clinical studies already performed successfully for indications such as hypertrophic scars and keloids, it can be said that the skin RAS is now in the critical phase of translation from preclinical evidence to clinical use.<\/jats:p>","DOI":"10.1111\/exd.14159","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T20:28:51Z","timestamp":1595449731000},"page":"891-901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The role of the renin\u2010angiotensin system in skin physiology and pathophysiology"],"prefix":"10.1111","volume":"29","author":[{"given":"Igor Maciel Souza","family":"Silva","sequence":"first","affiliation":[{"name":"Institute of Molecular Medicine Department of Cardiovascular and Renal Research University of Southern Denmark  Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper Bostlund","family":"Assersen","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine Department of Cardiovascular and Renal Research University of Southern Denmark  Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie Nanette","family":"Willadsen","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine Department of Cardiovascular and Renal Research University of Southern Denmark  Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine Department of Cardiovascular and Renal Research University of Southern Denmark  Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Artuc","sequence":"additional","affiliation":[{"name":"Department of Dermatology Charit\u00e9 \u2013 Medical Faculty Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5430-4275","authenticated-orcid":false,"given":"Ulrike Muscha","family":"Steckelings","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine Department of Cardiovascular and Renal Research University of Southern Denmark  Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2464-9_21"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2004.0139.x"},{"key":"e_1_2_8_4_1","volume":"70","author":"Aleksiejczuk M.","year":"2019","journal-title":"J. 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