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Several data support the involvement of the mammalian target of rapamycin complex 1 (mTORC1) signalling in the interplay between androgens, insulin, insulin\u2010like growth factor (IGF1) and high\u2010glycaemic index diet in acne. The peroxisome proliferator\u2013activated receptor \u03b3 (PPAR\u03b3) is involved in both differentiation and anti\u2010inflammatory response. Low differentiated sebocytes showed decreased expression of PPAR\u03b3 and increased level of insulin and IGF\u20101 receptors, resulting in the production of acne\u2010like sebum and inflammatory mediators. In this viewpoint, we discuss how in acne the dysregulation of proliferation and differentiation processes in sebocytes and keratinocytes may be associated with altered response to androgens and other hormones, such as insulin or IGF\u20101. Moreover, we propose PPAR\u03b3 modulation as an innovative therapeutic approach to normalize sebocyte differentiation process, interfering with the different mechanisms involved in altered pilosebaceous unit.<\/jats:p>","DOI":"10.1111\/exd.14168","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T03:51:39Z","timestamp":1597117899000},"page":"833-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Acne as an altered dermato\u2010endocrine response problem"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2000-006X","authenticated-orcid":false,"given":"Stefania","family":"Briganti","sequence":"first","affiliation":[{"name":"Cutaneous Physiopathology and Integrated Center of Metabolomics Research San Gallicano Dermatological Institute IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Flori","sequence":"additional","affiliation":[{"name":"Cutaneous Physiopathology and Integrated Center of Metabolomics Research San Gallicano Dermatological Institute IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Mastrofrancesco","sequence":"additional","affiliation":[{"name":"Cutaneous Physiopathology and Integrated Center of Metabolomics Research San Gallicano Dermatological Institute IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Ottaviani","sequence":"additional","affiliation":[{"name":"Cutaneous Physiopathology and Integrated Center of Metabolomics Research San Gallicano Dermatological Institute IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-01908-x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.09.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031122"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0b013e3181946a2c"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.11.017"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.048"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00725.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-016-9389-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17981"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.2.8472"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.10.004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-016-9390-z"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3870"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.144506"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12345"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12261252"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00924.x"},{"key":"e_1_2_6_19_1","first-page":"273","volume":"13","author":"Clatici V. 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