{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:50:16Z","timestamp":1787014216647,"version":"build-2736575974"},"reference-count":70,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The negative outcomes of COVID\u201019 diseases respiratory distress (ARDS) and the damage to other organs are secondary to a \u201ccytokine storm\u201d and to the attendant oxidative stress. Active hydroxyl forms of vitamin D are anti\u2010inflammatory, induce antioxidative responses, and stimulate innate immunity against infectious agents. These properties are shared by calcitriol and the CYP11A1\u2010generated non\u2010calcemic hydroxyderivatives. They inhibit the production of pro\u2010inflammatory cytokines, downregulate NF\u2010\u03ba\u0392, show inverse agonism on ROR\u03b3 and counteract oxidative stress through the activation of NRF\u20102. Therefore, a direct delivery of hydroxyderivatives of vitamin D deserves consideration in the treatment of COVID\u201019 or ARDS of different aetiology. We also recommend treatment of COVID\u201019 patients with high\u2010dose vitamin D since populations most vulnerable to this disease are likely vitamin D deficient and patients are already under supervision in the clinics. We hypothesize that different routes of delivery (oral and parenteral) will have different impact on the final outcome.<\/jats:p>","DOI":"10.1111\/exd.14170","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T19:48:02Z","timestamp":1597175282000},"page":"885-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["COVID\u201019 and Vitamin D: A lesson from the skin"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2929-1118","authenticated-orcid":false,"given":"Radomir M.","family":"Slominski","sequence":"first","affiliation":[{"name":"Department of Medicine and Microbiology Division of Clinical Immunology and Rheumatology Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2205-9893","authenticated-orcid":false,"given":"Joanna","family":"Stefan","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5829-7992","authenticated-orcid":false,"given":"Mohammad","family":"Athar","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6023-9062","authenticated-orcid":false,"given":"Michael F.","family":"Holick","sequence":"additional","affiliation":[{"name":"Department of Medicine Boston University Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0954-4445","authenticated-orcid":false,"given":"Anton M.","family":"Jetten","sequence":"additional","affiliation":[{"name":"Cell Biology Section National Institute of Environmental Health Sciences NIH Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7775-9988","authenticated-orcid":false,"given":"Chander","family":"Raman","sequence":"additional","affiliation":[{"name":"Department of Medicine and Microbiology Division of Clinical Immunology and Rheumatology Birmingham AL USA"},{"name":"Department of Dermatology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8963-3995","authenticated-orcid":false,"given":"Andrzej T.","family":"Slominski","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Alabama at Birmingham Birmingham AL USA"},{"name":"Veteran Administration Medical Center Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0695-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30628-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(20)30057-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6PP00355A"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.24494"},{"key":"e_1_2_8_7_1","first-page":"697","volume":"7","author":"Dankers W.","year":"2016","journal-title":"Front. 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