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We first mapped the HF response to cyclophosphamide (CYP) at natural anagen VI in mice. We found that 30\u201060\u00a0mg\/kg of CYP leads to dose\u2010dependent HF dystrophy that was spontaneously repaired with anagen resumption, while 120\u00a0mg\/kg of CYP prematurely induced catagen\/telogen entry. To explore how anagen HF repair is achieved in the dystrophic anagen pathway, we analysed the cell dynamics at 30\u00a0mg\/kg of CYP. Hair bulbs first shrunk due to matrix cell apoptosis associated with DNA double\u2010strand breaks. DNA damage was repaired, and ordered hair bulb structures were restored within 96\u00a0hours. Bulge stem cells did not undergo apoptosis nor proliferation. K5<jats:sup>+<\/jats:sup> basal lower proximal cup cells and outer root sheath cells quickly replenished the cells in the germinative zone and regenerated the concentric layered structures of the lower HF segment. Therefore, anagen HFs are able to summon extra\u2010bulge progenitor cells in close proximity to the damaged matrix for quick repair after CYP injury.<\/jats:p>","DOI":"10.1111\/exd.14175","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T03:45:12Z","timestamp":1597203912000},"page":"503-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Lower proximal cup and outer root sheath cells regenerate hair bulbs during anagen hair follicle repair after chemotherapeutic injury"],"prefix":"10.1111","volume":"30","author":[{"given":"Wen\u2010Yen","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Bon","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital and College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Chang","sequence":"additional","affiliation":[{"name":"Sophie Davis School of Biomedical Education City University of New York  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Fan","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering National Taiwan University  Taipei Taiwan"},{"name":"Division of Radiation Oncology Department of Oncology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiung\u2010Fei","family":"Chien","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery Department of Surgery Taipei Medical University Hospital  Taipei Taiwan"},{"name":"TMU Center for Cell Therapy and Regeneration Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-3464","authenticated-orcid":false,"given":"Sung\u2010Jan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering National Taiwan University  Taipei Taiwan"},{"name":"Department of Dermatology National Taiwan University Hospital and College of Medicine  Taipei Taiwan"},{"name":"Research Center for Developmental Biology and Regenerative Medicine National Taiwan University  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970929)386:3<379::AID-CNE4>3.0.CO;2-Z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.01.014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.38883"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-020-0624-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.031"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410706"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70553-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.358"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.354"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5394.2001.96007.pp.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23787.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13889"},{"key":"e_1_2_8_14_1","unstructured":"Longest head hair (female). 2004.http:\/\/www.guinnessworldrecords.com\/world-records\/longest-hair-(female)(accessed: July 2020)."},{"key":"e_1_2_8_15_1","first-page":"719","volume":"144","author":"Paus R.","year":"1994","journal-title":"Am. 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