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These scars are characterized by a supraphysiological vascular density and by the presence of pathological myofibroblasts (Hmyos) displaying a low apoptosis propensity. However, the nature of the association between these two hallmarks of hypertrophic scarring remains largely unexplored. Here, we show that Hmyos produce signalling entities known as microvesicles that significantly increase the three cellular processes underlying blood vessel formation: endothelial cell proliferation, migration and assembly into capillary\u2010like structures. The release of microvesicles from Hmyos was dose\u2010dependently induced by the serum protein \u03b1\u20102\u2010macroglobulin. Using flow cytometry, we revealed the presence of the \u03b1\u20102\u2010macroglobulin receptor\u2014low\u2010density lipoprotein receptor\u2010related protein 1\u2014on the surface of Hmyos. The inhibition of the binding of \u03b1\u20102\u2010macroglobulin to its receptor abolished the shedding of proangiogenic microvesicles from Hmyos. These findings suggest that the production of microvesicles by Hmyos contributes to the excessive vascularization of hypertrophic scars. \u03b1\u20102\u2010Macroglobulin modulates the release of these microvesicles through interaction with low\u2010density lipoprotein receptor\u2010related protein 1.<\/jats:p>","DOI":"10.1111\/exd.14178","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T05:05:43Z","timestamp":1598591143000},"page":"112-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Shedding of proangiogenic microvesicles from hypertrophic scar myofibroblasts"],"prefix":"10.1111","volume":"30","author":[{"given":"Alexandra","family":"Laberge","sequence":"first","affiliation":[{"name":"Centre de recherche en organogen\u00e8se exp\u00e9rimentale de l'Universit\u00e9 Laval\/LOEX Qu\u00e9bec QC Canada"},{"name":"Centre de recherche du CHU de Qu\u00e9bec\u2010Universit\u00e9 Laval Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mays","family":"Merjaneh","sequence":"additional","affiliation":[{"name":"Centre de recherche en organogen\u00e8se exp\u00e9rimentale de l'Universit\u00e9 Laval\/LOEX Qu\u00e9bec QC Canada"},{"name":"Centre de recherche du CHU de Qu\u00e9bec\u2010Universit\u00e9 Laval Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syrine","family":"Arif","sequence":"additional","affiliation":[{"name":"Centre de recherche en organogen\u00e8se exp\u00e9rimentale de l'Universit\u00e9 Laval\/LOEX Qu\u00e9bec QC Canada"},{"name":"Centre de recherche du CHU de Qu\u00e9bec\u2010Universit\u00e9 Laval Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Larochelle","sequence":"additional","affiliation":[{"name":"Centre de recherche en organogen\u00e8se exp\u00e9rimentale de l'Universit\u00e9 Laval\/LOEX Qu\u00e9bec QC Canada"},{"name":"Centre de recherche du CHU de Qu\u00e9bec\u2010Universit\u00e9 Laval Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2925-2784","authenticated-orcid":false,"given":"V\u00e9ronique J.","family":"Moulin","sequence":"additional","affiliation":[{"name":"Centre de recherche en organogen\u00e8se exp\u00e9rimentale de l'Universit\u00e9 Laval\/LOEX Qu\u00e9bec QC Canada"},{"name":"Centre de recherche du CHU de Qu\u00e9bec\u2010Universit\u00e9 Laval Qu\u00e9bec QC Canada"},{"name":"Department of Surgery Faculty of Medicine Universit\u00e9 Laval Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e3182374452"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2011.00692.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1985"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(03)00006-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-012-9253-5"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-017-9554-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27794"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(99)00040-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10415"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23771.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1994.1143"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-58456-5_13"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22268"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2011.10.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200302047"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.111.2.743"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.28.2.133"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2340\/0001555572331333","volume":"72","author":"Feldman S. 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