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Few cases of disease\u2010related cutaneous manifestations have been reported in the literature, and such manifestations are scarce. Integumentary manifestations from COVID\u201019 include exanthemas and papular dermatoses, urticarial eruptions, atopic dermatitis, vesiculobullous lesions and skin signs of hypercoagulable states, such as acral ischaemia, livedo and retiform purpura. Most common extracutaneous manifestations from the disease include headache, cough, anosmia, ageusia, fever, dyspnoea, nausea, diarrhoea and cardiovascular events. The objectives of this review were to discuss the role of human cell receptors described as interaction targets of SARS\u2010CoV\u20102, as well to understand the current state of knowledge on skin expression of these receptors, in order to substantiate future research. The authors present a thorough literature review on SARS\u2010CoV\u20102 and its possible interaction with cell receptors and human tissues including the skin. They discuss a molecular hypothesis to explain the lower prevalence of dermatological manifestations from direct SARS\u2010CoV\u20102 infection. Distinct human cell receptors binding the virus appear to be less expressed in the skin compared to other organs. Additionally, the presence of resolvins and the disintegrin metalloprotease ADAM17 provide a putative protection to the skin, explaining the majority of COVID\u201019 manifestations to be extracutaneous. This review represents an excellent opportunity for future studies using skin biopsies from COVID\u201019 patients to investigate molecular expression in the pathophysiology of cutaneous manifestations of the disease.<\/jats:p>","DOI":"10.1111\/exd.14186","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T23:19:52Z","timestamp":1598915992000},"page":"936-944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Potential interactions of SARS\u2010CoV\u20102 with human cell receptors in the skin: Understanding the enigma for a lower frequency of skin lesions compared to other tissues"],"prefix":"10.1111","volume":"29","author":[{"given":"Paulo","family":"Ricardo Criado","sequence":"first","affiliation":[{"name":"Dermatology Department Centro Universit\u00e1rio Sa\u00fade ABC Santo Andr\u00e9 Brazil"},{"name":"LIM\u201050 Faculdade de Medicina da Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1722-5970","authenticated-orcid":false,"given":"Thais Prota Hussein","family":"Pincelli","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta Fachini Jardim","family":"Criado","sequence":"additional","affiliation":[{"name":"Dermatology Department Centro Universit\u00e1rio Sa\u00fade ABC Santo Andr\u00e9 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice Martinez Zugaib","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Dermatology Department Centro Universit\u00e1rio Sa\u00fade ABC Santo Andr\u00e9 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Belda Junior","sequence":"additional","affiliation":[{"name":"LIM\u201050 Faculdade de Medicina da Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"281","volume":"87","author":"Singhal T.","year":"2020","journal-title":"Pediatrics"},{"key":"e_1_2_8_3_1","unstructured":"Coronavirus Resource Center of the John Hopkins University. 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