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Besides the primary structural\u2010functional defect, chronic tissue damage with induction and dysregulation of inflammatory pathways is a common pathogenic mechanism in EB. In localized variants, the inflammatory aberrations may mainly affect the micromilieu of lesional skin, while a systemic inflammatory response was shown to contribute to the systemic morbidity in severe EB subtypes with extensive cutaneous involvement. Our continued understanding of the pathophysiology of EB, as well as advances in molecular technologies, has paved the way for translational therapeutic approaches. The spectrum comprises of corrective and symptom\u2010relieving therapies that include innovative therapeutic options garnered from the bench, repurposed drugs approved for other diseases, as well as strategies for gene\u2010, protein\u2010 and cell\u2010based therapies. Immunological traits further define new targets of therapy, aimed at improving skin barrier restoration, microbial surveillance and infection control, wound healing and anti\u2010neoplastic effects. Clinical availability and feasibility of these approaches for all EB patients and subtypes are currently limited, reflecting issues of efficacy, specificity, tolerability and safety. A multistep targeting approach and highly individualized, risk\u2010stratified combinatory treatment plans will thus be essential for sustained efficacy and improved overall quality of life in EB.<\/jats:p>","DOI":"10.1111\/exd.14194","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T05:13:03Z","timestamp":1602479583000},"page":"1112-1122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Translational perspectives to treat Epidermolysis bullosa\u2014Where do we stand?"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5255-8140","authenticated-orcid":false,"given":"Christine","family":"Prodinger","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital of the Paracelsus Medical University Salzburg Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann W","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital of the Paracelsus Medical University Salzburg Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Laimer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital of the Paracelsus Medical University Salzburg Salzburg Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18921"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.052"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.053"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.10.017"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.01.016"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-9-76"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13979"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.11.036"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-020-00466-7"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01443-3"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073813495959"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.29245\/2572-9411\/2016\/3.1054"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0931-2"},{"key":"e_1_2_13_15_1","first-page":"e66","volume":"21","author":"Abrahamyan L.","year":"2014","journal-title":"J Popul. 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