{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:42:08Z","timestamp":1790192528864,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860551"],"award-info":[{"award-number":["81860551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is a common genetic disease characterized by hyperproliferation and disordered maturation of keratinocytes. To date, many association studies between psoriasis and VDR gene have been conducted, but the results are controversial. Furthermore, vitamin D<jats:sub>3<\/jats:sub> analogue has anti\u2010psoriatic activity; however, the clinical response is variable. This study was conducted to explore whether VDR gene polymorphisms are associated with psoriasis susceptibility and clinical response to calcipotriol in psoriatic patients. A total of 110 patients and 183 controls were genotyped for VDR gene polymorphisms rs2228570, rs731236, rs1544410 and rs7975232 by LDR method. SNP\u2010based and haplotype\u2010based association analyses were subsequently performed. Patients with PASI\u00a0&lt;\u00a03 were treated with calcipotriol ointment monotherapy. After 6\u00a0weeks of therapy, the correlations between efficacy and the genotypes of each polymorphism were evaluated. The results showed that for rs7975232, allele A was significantly over\u2010represented in psoriasis patients relative to controls (39.09% vs. 27.05%, OR (95% CI)\u00a0=\u00a01.731 (1.213\u20102.471)), and compared with the reference CC genotype, the following ORs were observed: AA genotype OR\u00a0=\u00a02.404 (95% CI: 1.085\u20105.328; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.034) and GA genotype OR\u00a0=\u00a02.143 (95% CI: 1.283\u20103.579; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005). Haplotype analyses showed that the rs2228570\/rs731236\/rs1544410\/rs7975232 CTGA was significantly over\u2010represented in psoriasis patients compared with controls (OR (95% CI)=1.907 (1.132\u20103.214); <jats:italic>P<\/jats:italic>\u00a0=\u00a0.020). Among the patients with PASI\u00a0&lt;\u00a03, the response rates to calcipotriol were significantly higher in patients with rs7975232 CC genotypes than in those with other genotypes (<jats:italic>x<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a09.172, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.010). These data suggest that VDR polymorphisms are associated with psoriasis susceptibility and clinical response to calcipotriol in psoriatic patients.<\/jats:p>","DOI":"10.1111\/exd.14202","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T15:35:56Z","timestamp":1601480156000},"page":"1186-1190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Vitamin D receptor gene polymorphisms are associated with psoriasis susceptibility and the clinical response to calcipotriol in psoriatic patients"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8516-122X","authenticated-orcid":false,"given":"Junlin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology the Second Affiliated Hospital Hainan Medical University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Haikou People\u2019s Hospital Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology the Second Affiliated Hospital Hainan Medical University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duoyan","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Dermatology the Second Affiliated Hospital Hainan Medical University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory the Second Affiliated Hospital Hainan Medical University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirui","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Dermatology the Second Affiliated Hospital Hainan Medical University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology the Second Affiliated Hospital Hainan Medical University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanliu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Dermatology the Second Affiliated Hospital Hainan Medical University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Health Examination Center the Second Affiliated Hospital Hainan Medical University Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590220005001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1970.tb02187.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1959.161"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12276343"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh169"},{"key":"e_1_2_9_7_1","first-page":"187","volume":"17","author":"Rucevi\u0107 B.\u2010D.","year":"2009","journal-title":"Acta Dermatovenerol. 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