{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:11:53Z","timestamp":1765041113634,"version":"3.40.5"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Damage\u2010associated molecular patterns (DAMPs) have drawn much attention as a member of disease\u2010associated molecules in systemic sclerosis (SSc). In this study, we investigated the potential contribution of S100A12, a member of DAMPs, to the development of SSc by evaluating S100A12 expression in the lesional skin and the clinical correlation of serum S100A12 levels. S100A12 expression was markedly elevated in the epidermis of SSc\u2010involved skin at protein levels and in the bulk skin at mRNA levels. The deficiency of transcription factor Fli1, a predisposing factor of SSc, enhanced S100A12 expression and Fli1 occupied the <jats:italic>S100A12<\/jats:italic> promoter in normal human keratinocytes. Serum S100A12 levels were higher in SSc patients, especially in those with diffuse cutaneous involvement, than in healthy controls and positively correlated with skin score. Furthermore, the presence of interstitial lung disease significantly augmented serum levels of S100A12. Importantly, serum S100A12 levels correlated inversely with both per cent forced vital capacity and per cent diffusing capacity for carbon monoxide and positively with serum levels of KL\u20106 and surfactant protein\u2010D. Collectively, these results indicate a possible contribution of S100A12 to skin sclerosis and interstitial lung disease associated with SSc, further supporting the critical roles of DAMPs in the pathogenesis of this disease.<\/jats:p>","DOI":"10.1111\/exd.14218","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T14:10:20Z","timestamp":1602943820000},"page":"409-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Serum S100A12 levels: Possible association with skin sclerosis and interstitial lung disease in systemic sclerosis"],"prefix":"10.1111","volume":"30","author":[{"given":"Jun","family":"Omatsu","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Saigusa","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Toyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Awaji","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Ikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Norimatsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Yoshizaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5560-9778","authenticated-orcid":false,"given":"Yoshihide","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14153"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.04.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.223"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000156958"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.120"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.253"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2305-4"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14459"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118677"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-205013"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-019-0240-4"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13269"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg385"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316655208"},{"journal-title":"J Int Med Res","article-title":"Serum S100A12 levels are correlated with clinical severity in patients with dermatomyositis\u2010associated interstitial lung disease","author":"Lou Y","key":"e_1_2_10_17_1"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160247"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.12.005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2020.3808"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63685-1"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10243.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6797"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.06.004"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.06.008"},{"journal-title":"Rheumatology","article-title":"Association of functional (GA)n microsatellite polymorphism in the FLI1 gene with susceptibility to human systemic sclerosis","author":"Yamashita K","key":"e_1_2_10_26_1"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2017.09.011"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.98850"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13900"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008264"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.09.007"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38901"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1520997112"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00313"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0713412"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4598"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.10.040"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40784"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201209-1602OC"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000262386.32287.29"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/01902148.2014.933985"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1601-87"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22696"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090593"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38948"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1521-3"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.04.035"},{"key":"e_1_2_10_48_1","first-page":"1268","article-title":"Localization of endothelin\u20101 and its binding sites in scleroderma skin","volume":"21","author":"Vancheeswaran R","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20883"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex280"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14218","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T18:26:36Z","timestamp":1693592796000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,29]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/exd.14218"],"URL":"https:\/\/doi.org\/10.1111\/exd.14218","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"type":"print","value":"0906-6705"},{"type":"electronic","value":"1600-0625"}],"subject":[],"published":{"date-parts":[[2020,10,29]]},"assertion":[{"value":"2020-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}