{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:37:22Z","timestamp":1791369442935,"version":"4.3.1"},"reference-count":87,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["802041"],"award-info":[{"award-number":["802041"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mast cells are innate immune cells located at many barrier sites in the body and known to protect the host against environmental threats and to be involved in allergic diseases. More recently, new studies have investigated their roles in the regulation of skin inflammation and transmission of pain and itch sensations. Mast cell signalling through the Mas\u2010related G protein\u2010coupled receptor (MRGPR) X2 or its mouse orthologue MRGPRB2 has been reported to be one of the major mechanism by which mast cell can regulate such processes. MRGPRX2 and MRGPRB2 can induce mast cell degranulation upon binding to a broad panel of cationic molecules such as neuropeptides, bacteria\u2010derived quorum sensing molecules, venom peptides, host defense peptides and, unfortunately, various FDA\u2010approved drugs. Upon activation, mast cells release granule\u2010associated proteases, lipids and multiple cytokines that can modulate vascular permeability, immune cells recruitment and activation status of tissue\u2010projecting nociceptive sensory neurons (ie nociceptors). Here, we discuss the modality of MRGPRX2\u2010dependent mast cell activation and its different consequences on the patterns of skin inflammation and associated diseases. We notably emphasize how MRGPRX2\u2010dependent skin mast cell activation might trigger various pathological traits such as pruritus, pain and inflammation and therefore become a potential therapeutic target for inflammatory pain, itch, atopic dermatitis and drugs\u2010induced injection site reactions.<\/jats:p>","DOI":"10.1111\/exd.14222","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T07:01:27Z","timestamp":1603782087000},"page":"193-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["MRGPRX2 sensing of cationic compounds\u2014A bridge between nociception and skin diseases?"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3415-238X","authenticated-orcid":false,"given":"Auriane","family":"Corbi\u00e8re","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Diff\u00e9renciation Epith\u00e9liale et Autoimmunit\u00e9 Rhumato\u00efde UMR 1056, INSERM, Universit\u00e9 de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-0169","authenticated-orcid":false,"given":"Alexia","family":"Loste","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Diff\u00e9renciation Epith\u00e9liale et Autoimmunit\u00e9 Rhumato\u00efde UMR 1056, INSERM, Universit\u00e9 de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5648-509X","authenticated-orcid":false,"given":"Nicolas","family":"Gaudenzio","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Diff\u00e9renciation Epith\u00e9liale et Autoimmunit\u00e9 Rhumato\u00efde UMR 1056, INSERM, Universit\u00e9 de Toulouse Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90785-3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00483-4"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192565799"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn815"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2004.10.007"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.113.008425"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4472-07.2008"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1732949100"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M314240200"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.018788"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-011-0862-7"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302456200"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14022"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.004"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.08.177"},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.4049\/jimmunol.127.2.788","volume":"127","author":"Tertian G","year":"1981","journal-title":"J Immunol"},{"key":"e_1_2_12_18_1","first-page":"440","volume":"10","author":"Abraham SN","year":"2010","journal-title":"Immunology"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)80010-7"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1460"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.6.3355"},{"key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4049\/jimmunol.147.1.247","volume":"147","author":"Irani AM","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.04.008"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.006"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-358432"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300300"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.01.012"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2038"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014080"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00993271"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03085"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.157.4.1693"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.009"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102796"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2009.10.007"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.01.008"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2017.10.012"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129697"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85538"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090805"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.89362"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.12.980"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.013"},{"key":"e_1_2_12_44_1","first-page":"893","volume":"137","author":"Zeltser R","year":"2001","journal-title":"Arch Dermatol"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335614"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.23.040183.001555"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.03.013"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14022"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppc.12267"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006640"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201746951"},{"key":"e_1_2_12_52_1","first-page":"161","volume":"6","author":"Yasuda M","year":"2013","journal-title":"J Pain Res"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.012"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146400"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14167"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01220.x"},{"key":"e_1_2_12_57_1","first-page":"81","volume":"55","author":"Scheynius A","year":"1984","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb05745.x"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2016.08.014"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.149"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201540983"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.02.089"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.04.008"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13533"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.08.013"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606490"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-8056-4_8"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.11.059"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax2945"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00149-X"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90434-4"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2006.00523.x"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2013.25.4.410"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0493-z"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.O-07-486"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI86359"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13199"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-11-41"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.10.4.673"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3120"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.004"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.06.003"},{"key":"e_1_2_12_83_1","first-page":"44400","volume":"278","author":"Robas N","year":"2003","journal-title":"M Fidock"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0698-3"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.03.088"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.277152"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801227"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.05.060"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14222","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T03:34:57Z","timestamp":1693712097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,17]]},"references-count":87,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/exd.14222"],"URL":"https:\/\/doi.org\/10.1111\/exd.14222","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,17]]},"assertion":[{"value":"2020-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}