{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:36:44Z","timestamp":1791419804470,"version":"4.3.3"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cutaneous lichen planus (CLP) and psoriasis (PSO) are both common chronic inflammatory skin diseases for which development of new treatments requires the identification of key targets. While PSO is a typical Th17\/IL\u201017\u2010disorder, there is some evidence that Th1\/IFN\u2010\u0263 dominate the inflammatory process in CLP. Nonetheless, the immunopathogenesis of CLP is not fully explained and key immunological factors still have to be recognized. In this study, we compared the immune signature of CLP lesions with the well\u2010characterized inflammation present in PSO skin. First, we analysed the histological and immunohistological characteristics of CLP and PSO. Second, we assessed the cytokine expression (\n                    <jats:italic>IL1A, IL1B, IL4, IL6, IL8, IL10, IL17A, IL19, IL21, IL22, IL23A, IL13, IFNG, TNF, IL12A, IL12B and IL36G)<\/jats:italic>\n                    of lesional skin of CLP with PSO by qPCR. Histology revealed a similar epidermal thickness in CLP and PSO. Immunohistochemically, both diseases presented with an inflammatory infiltrate mainly composed by CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells rather than CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    . Importantly, mRNA analysis showed a distinct cytokine signature: while levels of\n                    <jats:italic>IL12B<\/jats:italic>\n                    ,\n                    <jats:italic>IL1A<\/jats:italic>\n                    ,\n                    <jats:italic>IL6<\/jats:italic>\n                    and\n                    <jats:italic>IL23<\/jats:italic>\n                    were similar between the two groups, the characteristic PSO\u2010associated cytokines\n                    <jats:italic>IL8<\/jats:italic>\n                    ,\n                    <jats:italic>IL17A<\/jats:italic>\n                    ,\n                    <jats:italic>IL22<\/jats:italic>\n                    ,\n                    <jats:italic>IL19<\/jats:italic>\n                    and\n                    <jats:italic>IL36G<\/jats:italic>\n                    were expressed at very low levels in CLP. In contrast, CLP lesional skin was dominated by the expression of\n                    <jats:italic>IFNG<\/jats:italic>\n                    ,\n                    <jats:italic>IL21<\/jats:italic>\n                    ,\n                    <jats:italic>IL4<\/jats:italic>\n                    ,\n                    <jats:italic>IL12A and TNF<\/jats:italic>\n                    . Immunohistochemistry confirmed the dominance of IL\u201021, IFN\u2010\u0263 and also pSTAT1 in the dermal infiltrate of CLP, while IL\u201017A was more present in PSO. Collectively, this study improves our understanding of the immunological factors dominating CLP. The dominating cytokines and signalling proteins identified suggest that anti\u2010cytokine therapeutics like JAK inhibitors may be beneficial in CLP.\n                  <\/jats:p>","DOI":"10.1111\/exd.14226","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T17:03:30Z","timestamp":1603904610000},"page":"262-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["The inflammation in cutaneous lichen planus is dominated by IFN\u2010\u03d2 and IL\u201021\u2014A basis for therapeutic JAK1 inhibition"],"prefix":"10.1111","volume":"30","author":[{"given":"Katharina","family":"Pietschke","sequence":"first","affiliation":[{"name":"Department of Dermatology University Medical Center T\u00fcbingen Eberhard Karls University Tubingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Holstein","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center T\u00fcbingen Eberhard Karls University Tubingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center T\u00fcbingen Eberhard Karls University Tubingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"M\u00fcller\u2010Hermelink","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center T\u00fcbingen Eberhard Karls University Tubingen Germany"},{"name":"Department of Dermatology, Venereology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Gonzalez\u2010Menendez","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Neuropathology Eberhard Karls University of Tubingen and Comprehensive Cancer Center Tubingen University Hospital Tubingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Quintanilla\u2010Martinez","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Neuropathology Eberhard Karls University of Tubingen and Comprehensive Cancer Center Tubingen University Hospital Tubingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska C.","family":"Ghoreschi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzan","family":"Solimani","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5526-7517","authenticated-orcid":false,"given":"Kamran","family":"Ghoreschi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-35"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2015.2703"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1103641"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.82"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm804"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120225"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-019-00742-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02847"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-019-04509-x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615977"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16464"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.02.044"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav7561"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14703"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12232"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/701094"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2016.06.002"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13816"},{"issue":"2","key":"e_1_2_8_20_1","first-page":"e244","article-title":"Clinical healing of erosive oral lichen planus with tildrakizumab implicates the interleukin\u201023\/interleukin\u201017 pathway in the pathogenesis of lichen planus","volume":"61","author":"Ismail FF","year":"2019","journal-title":"Australas J Dermatol"},{"issue":"6","key":"e_1_2_8_21_1","first-page":"415","article-title":"Lichen planus pemphigoides treated with ustekinumab","volume":"100","author":"Knisley RR","year":"2017","journal-title":"Cutis"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01808"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09992.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155599750011606"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.532"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8140420"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(00)00167-5"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.08.041"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.234"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.02.044"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09447"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15686"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16003"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00527.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700945"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2711"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1429-3"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.6A7119.2007"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636385"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401740"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.025"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.08.048"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.280"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09033.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10793.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12718"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400775"},{"issue":"6","key":"e_1_2_8_48_1","first-page":"724","article-title":"CD56 highCD16 \u2010 NK cell involvement in cutaneous lichen planus","volume":"20","author":"Carbone T","year":"2010","journal-title":"Eur J Dermatol"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.06.001"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12550"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.58"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007614"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.11.5464"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164080"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.01.031"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12656"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2580"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.397"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14226","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14226","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T23:34:28Z","timestamp":1693697668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,12]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/exd.14226"],"URL":"https:\/\/doi.org\/10.1111\/exd.14226","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,12]]},"assertion":[{"value":"2020-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}