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The role of DPP4 and its inhibition in cutaneous dermatoses have been a recent point of investigation. DPP4 exerts a notable influence on T\u2010cell biology, the induction of skin\u2010specific lymphocytes, and the homeostasis between regulatory and effector T cells. Moreover, DPP4 interacts with a broad range of molecules, including adenosine deaminase, caveolin\u20101, CXCR4 receptor, M6P\/insulin\u2010like growth factor II\u2010receptor and fibroblast activation protein\u2010\u03b1, triggering downstream effects that modulate the immune response, cell adhesion and chemokine activity. DPP4 expression on melanocytes, keratinocytes and fibroblasts further alters cell function and, thus, has crucial implications in cutaneous pathology. As a result, DPP4 plays a significant role in bullous pemphigoid, T helper type 1\u2010like reactions, cutaneous lymphoma, melanoma, wound healing and fibrotic disorders. This review illustrates the multifactorial role of DPP4 expression, regulation, and inhibition in cutaneous diseases.<\/jats:p>","DOI":"10.1111\/exd.14228","type":"journal-article","created":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T03:27:32Z","timestamp":1604201252000},"page":"304-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["The role of Dipeptidyl Peptidase\u20104 in cutaneous disease"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1612-3887","authenticated-orcid":false,"given":"Payal M.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Illinois at Chicago Chicago IL 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