{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:09:40Z","timestamp":1767006580555,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of Riehl's melanosis (RM) is most common in the fifth or sixth decade of life with a female preponderance. As the skin is regarded a non\u2010reproductive organ on which sex steroid hormones act, a possible relationship between the pathogenesis of RM and sex steroid hormone receptors can be inferred. This study intended to evaluate the expression profile of oestrogen receptor (ER)\u03b2 and progesterone receptor (PR) in RM. Twelve lesional and perilesional normal\u2010appearing skin samples of RM patients and the skin of 12 healthy controls were retrieved for the analysis. Real\u2010time PCR analysis and immunohistochemical studies were conducted for ER\u03b2 and PR, respectively. The lesional and perilesional normal\u2010appearing skin of 12 patients with RM and the skin of 12 healthy controls were retrieved for the analysis. Interestingly, the dermal ER\u03b2 immunostaining intensity was increased more in lesional skin than in perilesional skin. When compared to healthy controls, increased expression of ER\u03b2 and PR mRNAs was observed in the lesional skin of patients with RM. Of note, epidermal and dermal ER\u03b2 and dermal PR expressions showed increased staining intensities in the lesional skin of RM patients compared with healthy controls. The altered expression of ER\u03b2 and PR in RM supports the possible role of these hormone receptors in the pathogenesis of RM.<\/jats:p>","DOI":"10.1111\/exd.14233","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T18:04:42Z","timestamp":1604426682000},"page":"396-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Paracrine roles of hormone receptors in Riehl\u2019s melanosis: A quantitative analysis of oestrogen and progesterone receptor expression patterns"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2903-9534","authenticated-orcid":false,"given":"Yu Ri","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Dermatology Incheon St. Mary\u2019s Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujin","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary\u2019s Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seo Won","family":"Jeong","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medical Research Yeouido St. Mary\u2019s Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary\u2019s Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"780","article-title":"Pigment Melanosis","volume":"30","author":"Riehl C","year":"1917","journal-title":"Wien klin Wchnschr"},{"issue":"5","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1684\/ejd.2018.3404","article-title":"Acquired diffuse slate\u2010grey facial dyspigmentation due to henna: an unrecognized cause of pigment contact dermatitis in Korean patients","volume":"28","author":"Woo YR","year":"2018","journal-title":"Eur J Dermatol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12376"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2004.04356.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41435-020-0096-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03638.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2008.00447.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1977.tb14245.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70071-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12477126"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2002.02051.x"},{"issue":"6","key":"e_1_2_8_13_1","first-page":"635","article-title":"Skin pigmentation and its regulation: role of keratinocyte and ovarian hormones on human melanocytes in vitro","volume":"34","author":"Yoon YH","year":"2001","journal-title":"Korean J Anatomy"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15104"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1996.tb00110.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1998.1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12745"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.069"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2002.17.1.58"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1088fje"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1650039"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2002.110601.x"},{"issue":"2","key":"e_1_2_8_23_1","first-page":"149","article-title":"Human cultured skin fibroblasts express estrogen receptor \u03b1 and \u03b2","volume":"10","author":"Haczynski J","year":"2002","journal-title":"Int J Mol Med"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00169"},{"issue":"10","key":"e_1_2_8_25_1","first-page":"1410","article-title":"Effect of 17 beta\u2010estradiol and phytoestrogen daidzein on the proliferation of pubocervical fascia and skin fibroblasts derived from women suffering from stress urinary incontinence","volume":"74","author":"Tomaszewski J","year":"2003","journal-title":"Ginekol. 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