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However,\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    can also invade, hide and persist in skin cells to contribute to wound chronicity. The intracellular life cycle of\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    is currently incompletely understood, although published studies indicate that its intracellular escape strategies play an important role in persistent cutaneous infections. This review provides current scientific knowledge about the intracellular life cycle of\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    in skin cells, which can be classified into professional and non\u2010professional antigen\u2010presenting cells, and its strategies to escape adaptive defense mechanisms. First, we discuss phenotypic switch of\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    , which affects intracellular routing and degradation. This review also evaluates potential intracellular escape mechanism of\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    to avoid intracellular degradation and antigen presentation, preventing an immune response. Furthermore, we discuss potential drug targets that can interfere with the intracellular life cycle of\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    . Taken together, this review aimed to increase scientific understanding about the intracellular life cycle of\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    into skin cells and its strategies to evade the host immune response, information that is crucial to reduce pathogenic invasion and life\u2010threatening persistence of\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    in chronic cutaneous infections.\n                  <\/jats:p>","DOI":"10.1111\/exd.14235","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T01:37:52Z","timestamp":1605145072000},"page":"1428-1439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Intracellular escape strategies of\n                    <i>Staphylococcus aureus<\/i>\n                    in persistent cutaneous 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