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In this study, we assessed the therapeutic effect of topical applied conjugated linoleic acid (CLA) on a murine AD model that was developed by repetitive applications of 2, 4\u2010dinitrofluorobenzene (DNFB). 2% or 5% CLA could markedly ameliorate AD\u2010like skin lesions, scratching behaviour and skin inflammation as evidenced by the reduced inflammatory blood cells, IgE and Th2\u2010related cytokine levels, and the infiltration of mast cells and inflammatory cells to the dermal tissues. Moreover, topical application with CLA modulated skin barrier repair including maintaining a balanced skin pH and increasing skin hydration, partially mediated by upregulating skin barrier\u2010related protein, filaggrin (FLG). In addition, topical CLA significantly dose\u2010dependently inhibited pro\u2010inflammatory cytokines including interleukin (IL)\u20106, IL\u20101\u03b2, tumour necrosis factor (TNF)\u2010\u03b1 and pro\u2010inflammatory enzyme expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase\u20102 (COX\u20102) in inflamed mice skin. Its anti\u2010inflammatory effect was associated with the inhibition of DNFB\u2010stimulated I\u03baB\u03b1 and NF\u2010\u03baB p65 phosphorylation in mouse skin. Taken together, our results suggest that locally applied CLA exerts potentially protective effects against AD lesional skin at least in part, due to regulation of skin barrier function and inflammatory response.<\/jats:p>","DOI":"10.1111\/exd.14242","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T22:39:08Z","timestamp":1605739148000},"page":"237-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Topical application with conjugated linoleic acid ameliorates 2, 4\u2010dinitrofluorobenzene\u2010induced atopic dermatitis\u2010like lesions in BALB\/c mice"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1599-7061","authenticated-orcid":false,"given":"Liu","family":"Tang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Wuhan University Wuhan 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