{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:59:59Z","timestamp":1765976399378,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitiligo pathophysiology is mediated by antigen\u2010specific cytotoxic T cells. Environmental stressors cause susceptible melanocytes to secrete damage\u2010associated molecular patterns (DAMPs). DAMPs are recognized by receptors such as the endocytic low\u2010density lipoprotein receptor\u2010related protein (LRP1\/CD91), expressed in antigen\u2010presenting cells, which activate self\u2010reactive CD8+ T cells, leading to melanocyte destruction. Within this response, interferon gamma triggers production of cytokine CXCL10, recruiting more activated T cells causing further melanocytic damage. We hypothesized that expression of LRP1\/CD91 was higher in vitiligo patients compared to non\u2010vitiligo individuals. And further that levels\/expression of CXCL10 in plasma were linked to disease severity. We enrolled forty individuals in this study: 18 patients with vitiligo and 22 healthy volunteers. We assessed LRP1\/CD91 expression and plasma CXCL10 in patients with vitiligo and healthy volunteers. Additionally, vitiligo patients received combined treatment for 16\u00a0weeks following which the said parameters were reassessed. Vitiligo Area Scoring Index was calculated before and after treatment for these patients. Analysis of LRP1\/CD91 MFI values in monocytes from vitiligo patients showed high surface levels of LRP1\/CD91 than from healthy volunteers (10.50\u00a0\u00b1\u00a00.77 vs. 6.55\u00a0\u00b1\u00a00.77 MFI units, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). This expression did not change after treatment. Plasma levels of CXCL10 were higher in vitiligo patients than healthy volunteers (93.78\u00a0\u00b1\u00a07.73 vs. 40.17\u00a0\u00b1\u00a06.25\u00a0pg\/ml). The patients with a good clinical response to treatment had a parallel reduction in plasma CXCL10 levels (105.8\u00a0\u00b1\u00a018.44 vs. 66.13\u00a0\u00b1\u00a04.87\u00a0pg\/ml) before and after treatment. LRP1\/CD91 expression may reflect susceptibility to vitiligo. Plasma levels of CXCL10 can represent a biomarker for monitoring treatment response. LRP1 and CXCL10 may represent therapeutic targets.<\/jats:p>","DOI":"10.1111\/exd.14249","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T07:25:25Z","timestamp":1606634725000},"page":"390-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["LRP1\/CD91 is highly expressed in monocytes from patients with vitiligo \u2013 even after repigmentation"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4481-5602","authenticated-orcid":false,"given":"Jaime","family":"Piquero\u2010Casals","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital of Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0126-158X","authenticated-orcid":false,"given":"Laura","family":"Mart\u00ednez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Immunology Hospital of Santa Creu i Sant Pau Biomedical Research Institute Sant Pau (IIB Sant Pau) Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2350-5282","authenticated-orcid":false,"given":"Agust\u00edn","family":"Alomar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital of Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7435-7868","authenticated-orcid":false,"given":"Eduardo","family":"Rozas\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital of Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2235-9893","authenticated-orcid":false,"given":"Candido","family":"Juarez","sequence":"additional","affiliation":[{"name":"Department of Immunology Hospital of Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6083-0952","authenticated-orcid":false,"given":"Luis","family":"Puig","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital of Santa Creu i Sant Pau Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60763-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2016.11.014"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.10.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12146"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.463"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.12.021"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14416"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(01)00526-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00353892"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00330.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb03306.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.28222"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00111-X"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-13-0132"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1524"},{"key":"e_1_2_10_18_1","first-page":"863041","article-title":"CD91\u2010dependent 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