{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T15:57:26Z","timestamp":1775923046694,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Topical immunotherapy with diphenylcyclopropenone (DPCP) is considered to be the most effective treatment of severe AA. However, the mechanism is unclear and an early predictor for the efficacy needs to be explored. The TSLP\/OX40L\/IL\u201013 pathway is an important pathway to initiate and maintain Th2 immune responses. Our previous work suggests this pathway may play a role in severe AA treated with DPCP. Thus, to further investigate the mechanism of TSLP\/OX40L\/IL\u201013 pathway in severe AA treated with DPCP and explore the predictor for the efficacy of DPCP therapy, we conducted a prospective study to compare expression levels of TSLP, OX40L, Th2 cytokines IL\u20104, IL\u20105 and IL13, and Th1 cytokine IFN\u2010\u03b3 in severe AA patients before and after the treatment. Results showed that 21 AA patients were responsive (responders) to the DPCP therapy and 12 were not responsive (non\u2010responders). Responders had lower levels of TSLP, OX40L and IL\u201013 than non\u2010responders before the treatment. After the DPCP treatment, TSLP, IL\u20105 and IL\u201013 increased and IFN\u2010\u03b3 decreased in responders while there were no changes of TSLP, IL\u20104, IL\u201013 and IFN\u2010\u03b3 in non\u2010responders. Our data suggest that the TSLP\/OX40L\/IL\u201013 pathway is down\u2010regulated in some severe AA patients and DPCP might play a therapeutic role by up\u2010regulating the pathway in these severe AA patients. The TSLP\/OX40L\/IL\u201013 pathway could be a predictor of response to the DPCP therapy for severe AA patients.<\/jats:p>","DOI":"10.1111\/exd.14254","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T06:50:05Z","timestamp":1608101405000},"page":"278-283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Diphenylcyclopropenone plays an effective therapeutic role by up\u2010regulating the TSLP\/OX40L\/IL\u201013 pathway in severe alopecia areata"],"prefix":"10.1111","volume":"30","author":[{"given":"Yugang","family":"Gong","sequence":"first","affiliation":[{"name":"Institute of Dermatology and Venereology Sichuan Academy of Medical Sciences &amp; Sichuan Provincial People\u2019s Hospital Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated 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