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Identifying and targeting pathways that bypass SMO could provide alternative treatments for patients with advanced or metastatic BCC. Here, we use a combination of RNA\u2010sequencing analysis of advanced human BCC tumor\u2013normal pairs and immunostaining of human and mouse BCC samples to identify an MTOR expression signature in BCC. Pharmacological inhibition of MTOR activity in BCC cells significantly reduces cell proliferation without affecting HH signalling. Similarly, treatment of the\n                    <jats:italic>\n                      Ptch1\u00a0\n                      <jats:sup>fl<\/jats:sup>\n                    <\/jats:italic>\n                    <jats:sup>\/<\/jats:sup>\n                    <jats:italic>\n                      <jats:sup>fl<\/jats:sup>\n                    <\/jats:italic>\n                    ;\n                    <jats:italic>Gli1<\/jats:italic>\n                    \u2010\n                    <jats:italic>\n                      Cre\n                      <jats:sup>ERT2<\/jats:sup>\n                    <\/jats:italic>\n                    mouse BCC tumor model with everolimus reduces tumor growth. aPKC, a downstream target of MTOR, shows reduced activity, suggesting that MTOR promotes tumor growth by activating aPKC and demonstrating that suppressing MTOR could be a promising target for BCC patients.\n                  <\/jats:p>","DOI":"10.1111\/exd.14255","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T02:27:36Z","timestamp":1607394456000},"page":"358-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["MTOR promotes basal cell carcinoma growth through atypical PKC"],"prefix":"10.1111","volume":"30","author":[{"given":"Rachel Y.","family":"Chow","sequence":"first","affiliation":[{"name":"Department of Developmental and Cell Biology University of California Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor M.","family":"Levee","sequence":"additional","affiliation":[{"name":"Department of Developmental and Cell Biology University of California Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurleen","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Developmental and Cell Biology University of California Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Cedeno","sequence":"additional","affiliation":[{"name":"Department of Developmental and Cell Biology University of California Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda T.","family":"Doan","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7407-9792","authenticated-orcid":false,"given":"Scott X.","family":"Atwood","sequence":"additional","affiliation":[{"name":"Department of Developmental and Cell Biology University of California Irvine CA USA"},{"name":"Department of Dermatology University of California Irvine CA USA"},{"name":"Chao Family Comprehensive Cancer Center University of California Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,20]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"NguyenTTL TaraporeE AtwoodSX.Common Skin Diseases \u2013 Skin Cancer. 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