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To mimic radiomucositis and radiodermatitis, non\u2010keratinized mucous membrane and normal human skin models were irradiated with 5 Gray. Afterwards, models were treated topically every second day with dexpanthenol\u2010containing ointment or liquid in comparison with placebo and untreated controls. On day 7 after irradiation, histological examination showed impairments in irradiated models. In contrast, models treated with dexpanthenol\u2010containing ointment or liquid showed a completely restored epidermal part. While gene expression profiling revealed an induction of genes related to a pro\u2010inflammatory milieu, oxidative stress and an impaired epidermal differentiation after irradiation of the models, aftercare treatment with dexpanthenol\u2010containing ointment or liquid revealed anti\u2010oxidative and anti\u2010inflammatory effects and had a positive effect on epidermal differentiation and structures important for physical and antimicrobial barrier function. Our findings confirm the potential of our established models as in vitro tools for the replacement of pharmacological in vivo studies regarding radiation\u2010induced skin injuries and give indications of the positive effects of dexpanthenol\u2010containing externals after radiation treatments as part of supportive tumor treatment.<\/jats:p>","DOI":"10.1111\/exd.14266","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T23:31:13Z","timestamp":1609975873000},"page":"745-750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Molecular effects of photon irradiation and subsequent aftercare treatment with dexpanthenol\u2010containing ointment or liquid in 3D models of human skin and non\u2010keratinized oral mucosa"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4701-3864","authenticated-orcid":false,"given":"Sebastian","family":"Huth","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology Medical Faculty RWTH Aachen University Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Marquardt","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Medical Faculty RWTH Aachen University Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Huth","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Medical Faculty RWTH Aachen University Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurenz","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Medical Faculty RWTH Aachen University 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