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Therefore, understanding the tissue environment in which immune activation occurs will enhance our capability to interfere with abnormal immune pathology. Here, we argue that studying the constitutively abnormal functions of clinically uninvolved psoriatic skin in patients with plaque type psoriasis is very important to better understand psoriasis pathobiology, because non\u2010lesional skin provides the tissue environment in which the psoriatic lesion develops. A key question in psoriasis is what initiates the abnormal, uncontrolled immune activation in the first place and the answer may lie in the skin. In light of this concept, we summarize abnormalities at the dermal\u2010epidermal junction region which shows a special \u201cnon\u2010healing\u2010like\u201d micro\u2010wound phenotype in the psoriatic non\u2010lesional skin that may act as a crucial susceptibility factor in the development of the disease.<\/jats:p>","DOI":"10.1111\/exd.14267","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T15:07:36Z","timestamp":1608649656000},"page":"765-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Could basement membrane alterations, resembling micro\u2010wounds at the dermo\u2010epidermal junction in psoriatic non\u2010lesional skin, make the skin susceptible to lesion 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