{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:11:33Z","timestamp":1790118693675,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chlorogenic acid (CGA) exhibits substantial biological function in antioxidant, antibacterial, anti\u2010lipogenesis and anti\u2010inflammatory activities. Increased sebum production and inflammation are considered important for the development of acne. However, the therapeutic effects of CGA on acne vulgaris remain unexplored. In this study, to assess the effects and underlying mechanisms of CGA on acne, a model of skin inflammation in ears of ICR mouse induced by living\n                    <jats:italic>Propionibacterium acnes<\/jats:italic>\n                    was used. 24 hours after 1.0\u00a0\u00d7\u00a0107\u00a0CFU,\n                    <jats:italic>P.\u00a0acnes<\/jats:italic>\n                    were intradermally injected into the ears of the ICR mouse. 1, 5 and 10\u00a0mg of CGA mixed with vaseline were applied to the surface of the skin every 12 hours for 3\u00a0days. Then, skin inflammation in the ears was assessed and the change of SREBP1 and TNF\u2010\u03b1 expression was analysed after CGA treatment. The mechanisms of CGA in anti\u2010inflammatory activity and lipogenesis were also studied in primary sebocytes and HaCaT cells. We found that CGA treatment effectively rescued ear swelling, redness and erythema skin in ears of ICR mouse induced by\n                    <jats:italic>P.\u00a0acnes<\/jats:italic>\n                    and significantly downregulated the expression of inflammatory cytokines by reducing the activity of the NF\u2010\u03baB signalling pathway. Furthermore, CGA could inhibit lipogenesis at the protein secretion and transcription level by decreasing the AKT\/mTOR\/SREBP signalling pathway. Our findings suggest that CGA could become a potential alternative drug for the treatment of acne vulgaris.\n                  <\/jats:p>","DOI":"10.1111\/exd.14277","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T02:51:11Z","timestamp":1610679071000},"page":"865-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Anti\u2010acne vulgaris effects of chlorogenic acid by anti\u2010inflammatory activity and lipogenesis inhibition"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7673-667X","authenticated-orcid":false,"given":"Jiao","family":"Luo","sequence":"first","affiliation":[{"name":"Institute for Translational Medicine the First Affiliated Hospital of Shenzhen University, Shenzhen Second People\u2019s Hospital Shenzhen China"},{"name":"Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen 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