{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:35:19Z","timestamp":1791588919905,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prurigo nodularis (PN) is a chronic skin dermatosis with hyperkeratotic and intensely pruritic nodules. Managing PN\u2010associated itch is difficult because its aetiology is still unknown. This study aimed to investigate the correlation between itch intensity in PN and the expression of a pruritogenic cytokine interleukin (IL)\u201031, its receptor complex components IL\u201031 receptor \u03b1 (IL\u201031RA) and oncostatin M receptor \u03b2 (OSMR\u03b2), and oncostatin M (OSM), which is a ligand of OSMR \u03b2, through immunofluorescence staining examination. Itch intensity in PN was closely correlated with the number of dermal IL\u201031(+) cells (Spearman's\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.551,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05), dermal IL\u201031RA(+) cells (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.475,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) and dermal OSM(+) cells (\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.505,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). In addition, the number of dermal OSMR\u03b2 (+) cells was increased in PN (\n                    <jats:italic>t<\/jats:italic>\n                    test,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05), despite not being correlated with itch intensity (Spearman's\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.375,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&gt;\u00a00.05). Major cellular sources of dermal IL\u201031 were T cells (27.0% of total IL\u201031\u2013expressing cells) and macrophages (35.0%), while those of OSM were mainly T cells (49.8%) and mast cells (26.8%). IL\u201031RA\u2013expressing dermal cells were mostly mast cells (49.3%) and macrophages (36.6%), and OSMR\u03b2 was mainly expressed by macrophages (51.8%) in the dermis. These findings indicate that IL\u201031 (mainly from macrophages and T cells) and OSM (principally from T cells and mast cells) stimulate dermal cells expressing IL\u201031RA and OSMR\u03b2 (e.g. macrophages), which may further promote itch and inflammation in PN. This complex dermal milieu of cell\/cytokine\/receptor network can be a therapeutic target for PN\u2010associated itch.\n                  <\/jats:p>","DOI":"10.1111\/exd.14279","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T01:22:04Z","timestamp":1610673724000},"page":"804-810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Itch intensity in prurigo nodularis is closely related to dermal interleukin\u201031, oncostatin M, IL\u201031 receptor alpha and oncostatin M receptor beta"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6779-5598","authenticated-orcid":false,"given":"Takashi","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Miami Itch Center Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery Miller School of Medicine University of Miami Miami Florida USA"},{"name":"Department of Dermatology National Defense Medical College Tokorozawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0895-7985","authenticated-orcid":false,"given":"Leigh A.","family":"Nattkemper","sequence":"additional","affiliation":[{"name":"Miami Itch Center Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery Miller School of Medicine University of Miami Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hei Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Miami Itch Center Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery Miller School of Medicine University of Miami Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina D.","family":"Kursewicz","sequence":"additional","affiliation":[{"name":"Miami Itch Center Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery Miller School of Medicine University of Miami Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Fowler","sequence":"additional","affiliation":[{"name":"Miami Itch Center Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery Miller School of Medicine University of Miami Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena M.","family":"Shah","sequence":"additional","affiliation":[{"name":"Miami Itch Center Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery Miller School of Medicine University of Miami Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Nanda","sequence":"additional","affiliation":[{"name":"Miami Itch Center Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery Miller School of Medicine University of Miami Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Fayne","sequence":"additional","affiliation":[{"name":"Miami Itch Center Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery Miller School of Medicine University of Miami Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Paolini","sequence":"additional","affiliation":[{"name":"Kiniksa Pharmaceuticals Corp Lexington Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Miami Itch Center Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery Miller School of Medicine University of Miami Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Yosipovitch","sequence":"additional","affiliation":[{"name":"Miami Itch Center Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery Miller School of Medicine University of Miami Miami Florida 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