{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:56Z","timestamp":1787014196238,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    With rising skin cancer rates and interest in preventing photoaging, adjuvants for sunscreens are in high demand. The potential of curcumin has been posited due to its anti\u2010inflammatory, antioxidant and wound healing properties. In prior studies, curcumin decreased UV\u2010induced inflammation, apoptotic changes in human keratinocytes and dermal fibroblasts, and the expression of matrix metalloproteinases. However, curcumin's utility has been hindered by poor aqueous solubility and rapid degradation\n                    <jats:italic>in vivo<\/jats:italic>\n                    . To overcome these limitations, we synthesized curcumin nanoparticles (curc\u2010np), which offer sustained topical delivery and enhanced bioavailability. Curc\u2010np and controls were applied to the skin of BALB\/c mice prior to UVB irradiation. Twenty\u2010four hours later, mice pretreated with curc\u2010np showed less erythema, induration and scale compared to controls. Histopathology showed fewer sunburn cells, and TUNEL assay indicated decreased apoptosis in curc\u2010np treated mice. Immunohistochemistry illustrated less p53 expression in skin pretreated with curc\u2010np. Furthermore, cytokine analysis revealed significantly less IL\u20106 and significantly greater anti\u2010inflammatory IL\u201010 in skin of curc\u2010np\u2010treated mice as compared to controls. Taken together, our results reinforce curcumin's established anti\u2010inflammatory effects in the skin and highlight its potential as a photoprotective adjuvant when delivered through nanoparticles. Further investigation alongside sunscreens against UV\u2010induced damage is warranted.\n                  <\/jats:p>","DOI":"10.1111\/exd.14282","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T19:29:00Z","timestamp":1610738940000},"page":"705-709","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Curcumin nanoparticles as a photoprotective adjuvant"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4782-2960","authenticated-orcid":false,"given":"Nagasai C.","family":"Adusumilli","sequence":"first","affiliation":[{"name":"Department of Dermatology The George Washington University School of Medicine and Health Sciences Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breanne","family":"Mordorski","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Nosanchuk","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Dermatology The George Washington University School of Medicine and Health Sciences Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.03.011"},{"key":"e_1_2_11_3_1","unstructured":"Sunscreen drug products for over\u2010the\u2010counter human use. Federal Register. Feb 26 2019.https:\/\/www.federalregister.gov\/d\/2019\u201003019. Accessed July 12 2020."},{"issue":"10","key":"e_1_2_11_4_1","first-page":"1131","article-title":"Curcumin: a novel treatment for skin\u2010related disorders","volume":"12","author":"Nguyen TA","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2012.08.010"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/593952"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2018.03.009"},{"issue":"5","key":"e_1_2_11_8_1","first-page":"7227","article-title":"Protective effect of curcumin against ultraviolet A irradiation\u2010induced photoaging in human dermal fibroblasts","volume":"17","author":"Liu X","year":"2018","journal-title":"Mol Med Rep"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190709210703"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/21691401.2016.1146736"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2014.09.004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120179"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1025-y"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2008.04.003"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.124"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.05.044"},{"issue":"8","key":"e_1_2_11_17_1","first-page":"937","article-title":"The basic science of natural ingredients","volume":"13","author":"Krausz A","year":"2014","journal-title":"J Drugs Dermatol"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14282","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14282","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T11:19:19Z","timestamp":1693567159000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,28]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/exd.14282"],"URL":"https:\/\/doi.org\/10.1111\/exd.14282","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,28]]},"assertion":[{"value":"2020-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}