{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:59:26Z","timestamp":1790499566775,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR 2497\/TP02 (GH133\/2\u20101)"],"award-info":[{"award-number":["FOR 2497\/TP02 (GH133\/2\u20101)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myeloid\u2010derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells, which are characterized by their capability to suppress T\u2010cell responses. While MDSCs have been traditionally associated with cancer diseases, their role as regulators of autoimmune diseases is emerging. Pemphigus is a chronic autoimmune blistering skin disease characterized by dysregulated T\u2010cell responses and autoantibody production. The role of MDSCs in pemphigus disease has not been defined yet. The aim of this study was to characterize MDSCs in pemphigus patients and to dissect their relationship with CD4<jats:sup>+<\/jats:sup> T\u2010cell subsets and clinical disease assessments. For this purpose, we performed a cross\u2010sectional analysis of 20 patients with pemphigus. Our results indicate that a population of CD66b<jats:sup>+<\/jats:sup>CD11b<jats:sup>+<\/jats:sup> polymorphonuclear\u2010like MDSCs (PMN\u2010MDSCs) is expanded in the peripheral blood mononuclear cell fraction of pemphigus patients compared to age\u2010matched healthy donors. These PMN\u2010MDSCs have the capability of suppressing allogeneic T\u2010cell proliferation <jats:italic>in vitro<\/jats:italic> and show increased expression of characteristic effector molecules such as arginase I and interleukin\u201010. We further demonstrate that PMN\u2010MDSCs are especially expanded in patients with active pemphigus, but not in patients in remission. Moreover, MDSC frequencies correlate with an increased Th2\/Th1 cell ratio. In conclusion, the identification of a functional PMN\u2010MDSC population suggests a possible role of these cells as regulators of Th cell responses in pemphigus.<\/jats:p>","DOI":"10.1111\/exd.14298","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T15:16:07Z","timestamp":1612538167000},"page":"782-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Arginase 1<sup>+<\/sup> IL\u201010<sup>+<\/sup> polymorphonuclear myeloid\u2010derived suppressor cells are elevated in patients with active pemphigus and correlate with an increased Th2\/Th1 response"],"prefix":"10.1111","volume":"30","author":[{"given":"Davide","family":"Neri","sequence":"first","affiliation":[{"name":"Molecular Immunology Charit\u00e9 (MIC) Department of Dermatology, Venereology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t of Berlin, and Berlin Institute of Health Berlin Germany"},{"name":"Department of Pediatrics 1 Medical Center T\u00fcbingen Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Carevic\u2010Neri","sequence":"additional","affiliation":[{"name":"Molecular Immunology Charit\u00e9 (MIC) Department of Dermatology, Venereology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t of Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Br\u00fcck","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical Center T\u00fcbingen Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Holstein","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical Center T\u00fcbingen Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical Center T\u00fcbingen Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzan","family":"Solimani","sequence":"additional","affiliation":[{"name":"Molecular Immunology Charit\u00e9 (MIC) Department of Dermatology, Venereology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t of Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Handgretinger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics 1 Medical Center T\u00fcbingen Eberhard Karls University T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Hartl","sequence":"additional","affiliation":[{"name":"Department of Pediatrics 1 Medical Center T\u00fcbingen Eberhard Karls University T\u00fcbingen Germany"},{"name":"Novartis Institutes for Biomedical Research Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5526-7517","authenticated-orcid":false,"given":"Kamran","family":"Ghoreschi","sequence":"additional","affiliation":[{"name":"Molecular Immunology Charit\u00e9 (MIC) Department of Dermatology, Venereology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t of Berlin, and Berlin Institute of Health Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4505"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2506"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701069"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3175"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12150"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0311177"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-099226"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-031856"},{"issue":"12","key":"e_1_2_8_10_1","first-page":"4756","article-title":"Activated granulocytes and granulocyte\u2010derived hydrogen peroxide are the underlying mechanism of suppression of t\u2010cell function in advanced cancer patients","volume":"61","author":"Schmielau J","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1299"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-317321"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2017.07.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201948240"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39767"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aae0482"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-15-281"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205508"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31778-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90360-B"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70183-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13409"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01387"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13711"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01413"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28547"},{"issue":"20","key":"e_1_2_8_27_1","first-page":"31624","article-title":"Immunophenotyping in pemphigus reveals a T(H)17\/T(FH)17 cell\u2010dominated immune response promoting desmoglein1\/3\u2010specific autoantibody production","volume":"0091","author":"Holstein J","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01836.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03901.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.10.6468"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.05.032"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.03.036"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00321"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01069.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14405"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22269"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61737-979-6_17"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2018.1470929"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300654"},{"key":"e_1_2_8_40_1","article-title":"Clinical relevance of polymorphonuclear myeloid\u2010derived suppressor cells in autoimmune\u2010blistering disorders pemphigus vulgaris and bullous pemphigoid","author":"Oktem A","year":"2020","journal-title":"J Invest Dermatol"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401081"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148919"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.588315"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6621"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.4.1841"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.10.6095"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-287839"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-624163"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.08.271"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.02.001"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9783-z"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200086"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.09.012"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14298","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T13:52:02Z","timestamp":1693403522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/exd.14298"],"URL":"https:\/\/doi.org\/10.1111\/exd.14298","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,23]]},"assertion":[{"value":"2020-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}