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We studied 617 cases of skin neoplasms (615 patients, 70 melanomas, 122 basal cell carcinomas, 12 squamous cell carcinomas and 413 benign tumors) in vivo with a portable setup. The studies considered the patients examined by GPs in local clinics and directed to a specialized Oncology Dispensary with suspected skin cancer. Each sample was histologically examined after excisional biopsy. The spectra were classified with a projection on latent structures and discriminant analysis. To check the classification models stability, a 10\u2010fold cross\u2010validation was performed. We obtained ROC AUCs of 0.75 (0.71\u20130.79; 95% CI), 0.69 (0.63\u20130.76; 95% CI) and 0.81 (0.74\u20130.87; 95% CI) for classification of a) malignant and benign tumors, b) melanomas and pigmented tumors and c) melanomas and seborrhoeic keratosis, respectively. The positive and negative predictive values ranged from 20% to 52% and from 73% to 99%, respectively. The biopsy ratio varied from 0.92:1 to 4.08:1 (at sensitivity levels from 90% to 99%). The accuracy of automatic analysis with the proposed system is higher than the accuracy of GPs and trainees, and is comparable or less to the accuracy of trained dermatologists. The proposed approach may be combined with other optical techniques of skin lesion analysis, such as dermoscopy\u2010 and spectroscopy\u2010based computer\u2010assisted diagnosis systems to increase accuracy of neoplasms classification.<\/jats:p>","DOI":"10.1111\/exd.14301","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T09:54:03Z","timestamp":1612950843000},"page":"652-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["<i>In vivo<\/i>\n                    diagnosis of skin cancer with a portable Raman spectroscopic device"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-7064","authenticated-orcid":false,"given":"Ivan A.","family":"Bratchenko","sequence":"first","affiliation":[{"name":"Department of Laser and Biotechnical Systems Samara University Samara Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyudmila A.","family":"Bratchenko","sequence":"additional","affiliation":[{"name":"Department of Laser and Biotechnical Systems Samara University Samara Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A.","family":"Moryatov","sequence":"additional","affiliation":[{"name":"Department of Oncology Samara State Medical University Samara Russia"},{"name":"Department of Visual Localization Tumors Samara Regional Clinical Oncology Dispensary Samara Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia A.","family":"Khristoforova","sequence":"additional","affiliation":[{"name":"Department of Laser and Biotechnical Systems Samara University Samara Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry N.","family":"Artemyev","sequence":"additional","affiliation":[{"name":"Department of Laser and Biotechnical Systems Samara University Samara Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg O.","family":"Myakinin","sequence":"additional","affiliation":[{"name":"Department of Laser and Biotechnical Systems Samara University Samara Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey E.","family":"Orlov","sequence":"additional","affiliation":[{"name":"Department of Visual Localization Tumors Samara Regional Clinical Oncology Dispensary Samara Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey V.","family":"Kozlov","sequence":"additional","affiliation":[{"name":"Department of Oncology Samara State Medical University Samara Russia"},{"name":"Department of Visual Localization Tumors Samara Regional Clinical Oncology Dispensary Samara Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery P.","family":"Zakharov","sequence":"additional","affiliation":[{"name":"Department of Laser and Biotechnical Systems Samara University Samara Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.54.1.8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.09.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.137.12.1627"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA04164D"},{"key":"e_1_2_9_7_1","unstructured":"Cochrane Library Special Collection: Diagnosing skin cancer.2020. https:\/\/www.cochrane.org\/news\/cochrane\u2010library\u2010special\u2010collection\u2010diagnosing\u2010skin\u2010cancer"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1533\/9780857097545.3.325"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201200230"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-013-1423-3"},{"key":"e_1_2_9_11_1","first-page":"1003704","article-title":"Spectral biopsy for skin cancer diagnosis: initial clinical results","author":"Austin JM","year":"2017","journal-title":"Proc. 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