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RDEB\u2010SCC cultured cell lines were treated with RDEB and non\u2010RDEB fibroblast conditioned media and assayed for migration and invasion with and without small molecule inhibitors for TGF\u03b2 and other downstream signal transduction pathways. TGF\u03b21 secreted by RDEB dermal fibroblasts has been found to induce migration and invasion and to increase expression of epithelial\u2010to\u2010mesenchymal transition markers in an RDEB\u2010SCC line. These effects were reversed upon inhibition of TGF\u03b2 signalling and its downstream pathways MEK\/ERK, P38 kinase and SMAD3. A number of small molecule inhibitors for these pathways are in different phases of various clinical trials and may be applicable to RDEB\u2010SCC patients. Studying the mechanisms of the extreme form RDEB\u2010SCC may inform studies of other types of SCC, as well as lead to better therapies for RDEB patients.<\/jats:p>","DOI":"10.1111\/exd.14304","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T04:03:25Z","timestamp":1613621005000},"page":"664-675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Role of transforming growth factor\u2010\u03b21 in recessive dystrophic epidermolysis bullosa squamous cell carcinoma"],"prefix":"10.1111","volume":"30","author":[{"given":"Kirk","family":"Twaroski","sequence":"first","affiliation":[{"name":"Stem Cell Institute University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Chen","sequence":"additional","affiliation":[{"name":"Stem Cell Institute University of Minnesota Minneapolis MN 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