{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:01:53Z","timestamp":1780437713904,"version":"3.54.1"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["NIH 5R01AR070245\u201003"],"award-info":[{"award-number":["NIH 5R01AR070245\u201003"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hair follicle stem cells (HFSCs) are known to be responsible for the initiation of a new hair cycle, but typically remain quiescent for very long periods. In alopecia, or hair loss disorders, follicles can be refractory to activation for years or even permanently. Alopecia can be triggered by autoimmunity, age, chemotherapeutic treatment, stress, disrupted circadian rhythm or other environmental insults. We previously showed that hair follicle stem cells and the hair cycle can be manipulated by regulation of pyruvate entry into mitochondria for subsequent oxidation to fuel the TCA cycle in normal adult mice with typical hair cycling. Here, we present new data from our efforts to develop murine models of alopecia based on environmental triggers that have been shown to do the same in human skin. We found that inhibition of pyruvate transport into mitochondria can accelerate the hair cycle even during refractory hair cycling due to age, repeated chemotherapeutic treatment and stress. Hair cycle acceleration in these alopecia models led to the formation of histologically normal hair follicles within 30\u201340\u00a0days of treatment without any overt signs of toxicity or deleterious effects. Therefore, we propose inhibition of pyruvate entry into mitochondria as a versatile treatment strategy for alopecia in humans.<\/jats:p>","DOI":"10.1111\/exd.14307","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T12:14:54Z","timestamp":1616156094000},"page":"448-456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Inhibition of pyruvate oxidation as a versatile stimulator of the hair cycle in models of alopecia"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3112-8934","authenticated-orcid":false,"given":"Aimee","family":"Flores","sequence":"first","affiliation":[{"name":"Department of Molecular Cell and Developmental Biology UCLA Los Angeles CA USA"},{"name":"Pelage Pharmaceuticals, Inc. Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-0942","authenticated-orcid":false,"given":"Sekyu","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology Harvard University Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0178-7373","authenticated-orcid":false,"given":"Ya\u2010Chieh","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biology Harvard University Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2932-2276","authenticated-orcid":false,"given":"William E.","family":"Lowry","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell and Developmental Biology UCLA Los Angeles CA USA"},{"name":"Pelage Pharmaceuticals, Inc. Los Angeles CA USA"},{"name":"Division of Dermatology David Geffen School of Medicine UCLA Los Angeles CA USA"},{"name":"Molecular Biology Institute UCLA Los Angeles CA USA"},{"name":"Broad Center for Regenerative Medicine UCLA Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02793"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.2004.07209004.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(01)00022-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.38"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092436"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12169.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-202X(93)90496-5"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.12.009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.200900033"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2008.73.024"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700376"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.10.003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.11.005"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2009.12.010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0544"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.9140"},{"key":"e_1_2_9_18_1","first-page":"57760","article-title":"Mapping metabolism: monitoring lactate dehydrogenase activity directly in tissue","volume":"136","author":"Jelinek D","year":"2018","journal-title":"J Vis Exp"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3575"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.10.021"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.08.011"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000211272"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12476744"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12475232"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2004.12.005"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.4049\/jimmunol.153.5.2180","article-title":"Tenidap modulates cytoplasmic pH and inhibits anion transport in vitro. 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