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Since UFPs reach blood circulation from lung alveoli, deep skin is very likely contaminated by PAHs coming from either skin surface or blood. As photoreactive, benzo(a)pyrene (BaP) or indenopyrene (IcdP) is involved in the interplay between pollution and sunlight. In order to better characterize this process, experiments were carried out on reconstructed human epidermis (RHE) in a protocol mimicking realistic exposure. Concentrations of PAHs comparable to those generally reported in blood were used together with chronic irradiation to low dose UVA1. On a histological level, damaged cells mainly accumulated in a suprabasal situation, thus reducing living epidermis thickness. Stress markers such as IL1\u2010\u03b1 or MMP3 secretion increased, and surprisingly, the histological position of Transglutaminase\u20101 within epidermis was disturbed, whereas position of other differentiation markers (keratin\u201010, filaggrin, loricrin) remained unchanged. When vitamin C was added in culture medium, a very significant protection involving all markers was noticed. In conclusion, we provide here a model of interest to understand the epidermal deleterious consequences of pollution and to select efficient protective compounds.<\/jats:p>","DOI":"10.1111\/exd.14315","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T15:13:05Z","timestamp":1615475585000},"page":"1693-1698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vitamin C prevents epidermal damage induced by PM\u2010associated pollutants and UVA1 combined exposure"],"prefix":"10.1111","volume":"30","author":[{"given":"Ariane","family":"Dimitrov","sequence":"first","affiliation":[{"name":"L\u2019OREAL R&amp;I Advanced Research Aulnay sous Bois France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Zanini","sequence":"additional","affiliation":[{"name":"L\u2019OREAL R&amp;I Advanced Research Aulnay sous Bois 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