{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:48Z","timestamp":1787014188288,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Expression of microRNAs (miRNAs) is often dysregulated in several cancers, including non\u2010melanoma skin cancer (NMSC). Individuals with vitiligo possess a deregulated miRnome along with a lower risk of developing NMSCs. We used data sets from our previously published studies on vitiligo epidermis to construct functional miRNA\u2010mRNA networks to understand the molecular basis underlying the lower incidence of NMSC observed in individuals with vitiligo. miRTarBase database was used to fetch the experimentally validated targets of differentially expressed miRNAs and two protein\u2010protein interaction (PPI) networks were constructed for the miRNA\u2010mRNA interactions (230 downregulated targets of 5 upregulated miRNAs and 47 upregulated mRNAs targeted by 12 downregulated miRNAs). Pathway enrichment analysis identified RNA biogenesis and transport as well as cell adhesion to be perturbed in vitiligo. Further, oncogenic transcription factors (OTFs) that were upregulated in publicly available squamous cell carcinoma (SCC) or basal cell carcinoma (BCC) microarray data were compared with that of vitiligo to decode skin cancer\u2010specific molecular signatures. We identified three significantly upregulated miRNAs, miR\u201031\u20105p, miR\u201031\u20103p and miR\u2010194\u20103p in lesional epidermis that could negatively regulate seven oncogenic transcription factors, FOXC1, AR, SP1, YY1, GLI2, TP53 and RARA, known to be over\u2010expressed in SCC or BCC. Taken together, our study identified a perturbed miRNA\u2010regulated transcriptome, which potentially confers protection to vitiligo skin from an increased incidence of NMSC.<\/jats:p>","DOI":"10.1111\/exd.14317","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:25:38Z","timestamp":1615163138000},"page":"1309-1319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Integrated analysis of miRNA\u2010mRNA networks reveals a strong anti\u2010skin cancer signature in vitiligo epidermis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-9489","authenticated-orcid":false,"given":"Archana","family":"Singh","sequence":"first","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology New Delhi India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aayush","family":"Gupta","sequence":"additional","affiliation":[{"name":"Dr. D. 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