{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:46:27Z","timestamp":1792525587562,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,14]],"date-time":"2021-03-14T00:00:00Z","timestamp":1615680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Galectin\u201010 (Gal\u201010) is a key molecule involved in eosinophil\u2010mediated suppression of T\u2010cell immune response. Systemic sclerosis (SSc) is characterized by T helper (Th) 2\/Th17 immune response and impaired function of regulatory T cells, but the pathological role of Gal\u201010\u00a0has not been studied so far. Therefore, we investigated the clinical correlation of serum Gal\u201010 levels in SSc patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum Gal\u201010 levels were determined by enzyme\u2010linked immunosorbent assay in 38 patients with diffuse cutaneous SSc (dcSSc), 30 with limited cutaneous SSc and 20 healthy controls. Clinical correlations of serum Gal\u201010 levels were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum Gal\u201010 levels were significantly lower in SSc patients than in healthy controls, especially in dcSSc patients, and inversely correlated with skin score, the percentage of predicted diffusion lung capacity for carbon monoxide and estimated right ventricular systolic pressure (RVSP). Furthermore, serum Gal\u201010 levels had negative correlations with leucocyte counts and inflammatory parameters. Multivariate regression analysis identified C\u2010reactive protein and RVSP as explanatory parameters for serum Gal\u201010 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Decreased serum Gal\u201010 levels may reflect the impairment of eosinophil\u2010mediated regulatory system for T\u2010cell immune response in SSc, possibly contributing to pulmonary vascular involvement leading to pulmonary arterial hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/exd.14320","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T06:33:44Z","timestamp":1615790024000},"page":"959-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A potential contribution of decreased serum galectin\u201010 levels to systemic inflammation and pulmonary vascular involvement in systemic 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