{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:39:43Z","timestamp":1792175983370,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T00:00:00Z","timestamp":1617408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The stratum corneum (SC) is key in the maintenance of the biomechanical barrier and hydration of skin. Our previous investigations showed beneficial effects of a combination of emollients on water capture and retention and protein and lipid organization, all of which are linked to dryness and dry skin damage. Here, we show how a formulation containing an emollient combination (\u201cTrio\u201d) and its basal formulation (placebo) impacted the descriptors of SC hydration in SC layers. Only the Trio formulation\u2014not its placebo formulation\u2014modified SC biomechanical drying stress behaviour and imparted a high capacity to protect it from dehydration. This was in accordance with findings at the molecular level using Raman analyses and at the structural level using cryo\u2010scanning electron microscopy (SEM). After topical application, only the Trio formulation profoundly increased lateral packing of lipids and their compactness. Cryo\u2010SEM showed that, unlike the placebo formulation, the Trio formulation prevented the water loss when applied before the dehydration process. In conclusion, these studies demonstrate that stresses in the SC due to dehydration can be alleviated using a formulation containing emollients that interact with the SC lipid components.<\/jats:p>","DOI":"10.1111\/exd.14331","type":"journal-article","created":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T03:41:21Z","timestamp":1617421281000},"page":"1352-1357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Comprehensive characterization of the structure and properties of human stratum corneum relating to barrier function and skin hydration: modulation by a moisturizer formulation"],"prefix":"10.1111","volume":"30","author":[{"given":"Marie\u2010Florence","family":"Galliano","sequence":"first","affiliation":[{"name":"Center of Research Pierre Fabre Dermo\u2010Cosmetics (PFDC Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Tfayli","sequence":"additional","affiliation":[{"name":"Lip(sys)2, EA7357, ex Analytical Chemistry Analytical Chemistry Group of Paris\u2010Sud (GCAPS\u2010EA4041 Faculty of Pharmacy Univ. Paris\u2010Sud University Paris\u2010Saclay Chatenay\u2010Malabry France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3989-362X","authenticated-orcid":false,"given":"Reinhold H.","family":"Dauskardt","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Stanford University Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Payre","sequence":"additional","affiliation":[{"name":"Centre de Microscopie Electronique CMEAB Universit\u00e9 de Toulouse III\u2010Paul Sabatier Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Center of Research Pierre Fabre Dermo\u2010Cosmetics (PFDC Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Bessou\u2010Touya","sequence":"additional","affiliation":[{"name":"Center of Research Pierre Fabre Dermo\u2010Cosmetics (PFDC Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlette","family":"Baillet\u2010Guffroy","sequence":"additional","affiliation":[{"name":"Lip(sys)2, EA7357, ex Analytical Chemistry Analytical Chemistry Group of Paris\u2010Sud (GCAPS\u2010EA4041 Faculty of Pharmacy Univ. Paris\u2010Sud University Paris\u2010Saclay Chatenay\u2010Malabry France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-8070","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Duplan","sequence":"additional","affiliation":[{"name":"Center of Research Pierre Fabre Dermo\u2010Cosmetics (PFDC Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.08.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2009.00557.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12455817"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(96)00006-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13721"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2010.00568.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206851109"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09937.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12277392"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01320.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00596.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2012.00743.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.11.011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201300169"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2004.00047.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08703.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12132"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14331","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14331","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T19:01:02Z","timestamp":1692817262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,3]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/exd.14331"],"URL":"https:\/\/doi.org\/10.1111\/exd.14331","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,3]]},"assertion":[{"value":"2020-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}