{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:30:05Z","timestamp":1791495005506,"version":"4.3.4"},"reference-count":166,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The observed incidence of psoriasis has been gradually increasing over time (J Am Acad Dermatol, 03, 2009, 394), but the underlying pathogenic factors have remained unclear. Recent studies suggest the importance of epigenetic modification in the pathogenesis of psoriasis. Aberrant epigenetic patterns including changes in DNA methylation, histone modifications and non\u2010coding RNA expression are observed in psoriatic skin. Reversing these epigenetic mechanisms has showed improvement in psoriatic phenotypes, making epigenetic therapy a potential avenue for psoriasis treatment. Here, we summarize relevant evidence for epigenetic dysregulation contributing to psoriasis susceptibility and pathogenesis, and the factors responsible for epigenetic modifications, providing directions for potential future clinical avenues.<\/jats:p>","DOI":"10.1111\/exd.14332","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T17:12:53Z","timestamp":1616519573000},"page":"1156-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Dysregulated epigenetic modifications in psoriasis"],"prefix":"10.1111","volume":"30","author":[{"given":"Chang","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lam C.","family":"Tsoi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan Ann Arbor MI USA"},{"name":"Department of Computational Medicine and Bioinformatics and Department of Biostatistics University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-0812","authenticated-orcid":false,"given":"Johann E.","family":"Gudjonsson","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Michigan Ann Arbor MI USA"},{"name":"A. Alfred Taubman Medical Research Institute Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-35"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.2014.914437"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34293-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1087-0024.2003.09102.x"},{"issue":"4","key":"e_1_2_9_8_1","first-page":"26","article-title":"Treatment satisfaction among patients with moderate\u2010to\u2010severe psoriasis","volume":"8","author":"Finch T","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01549"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495291"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm72"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.09.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15382"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000106419"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12375"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.53.3-4.289"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00068.2010"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20170053"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/hdy.2010.54"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.103.023796"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2217\/nmt-2018-0004"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.05.008"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers5020676"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0153-y"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.110"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205609"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.22"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2016.12.005"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500398102"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230184"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-111314-035900"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-019-0095-0"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg887"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2008.08.006"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510378683"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-013-0223-4"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1190614"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.112"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.03.005"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.042"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.01.001"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.348"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-018-0541-9"},{"key":"e_1_2_9_44_1","first-page":"161","article-title":"Methylation in psoriasis. Does sex matter?","volume":"35","author":"Llamas\u2010Velasco M","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0274-0"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08505.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181268"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.12.029"},{"key":"e_1_2_9_49_1","first-page":"11","article-title":"CYP2S1 might regulate proliferation and immune response of keratinocyte in psoriasis","volume":"12","author":"Sheng Y","year":"2020","journal-title":"Epigenetics"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.06.020"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08683"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-020-03045-9"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2018.07.011"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-015-0087-z"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.10.016"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2016.01.020"},{"issue":"4","key":"e_1_2_9_57_1","first-page":"1941","article-title":"TET2 is involved in DNA hydroxymethylation, cell proliferation and inflammatory response in keratinocytes","volume":"21","author":"Liu X","year":"2020","journal-title":"Mol Med Rep"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.07.011"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.04.128"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13325"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002454"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2014.938165"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr500350x"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8303-z"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03704-z"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13790"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03028-1"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI134217"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.004"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjv022"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2011.1383"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129269"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02962.x"},{"issue":"9","key":"e_1_2_9_74_1","first-page":"157","article-title":"Histone deacetylase 1 and sirtuin 1 expression in psoriatic skin: a comparison between guttate and plaque psoriasis","volume":"10","author":"Hwang YJ","year":"2020","journal-title":"Life (Basel)"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072356"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1652"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-133967"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19380"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2212-y"},{"issue":"1","key":"e_1_2_9_80_1","first-page":"157","article-title":"Abnormal expression of SIRTs in psoriasis: decreased expression of SIRT 1\u20135 and increased expression of SIRT 6 and 7","volume":"44","author":"Fan X","year":"2019","journal-title":"Int J Mol Med"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.044"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4332"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.06.001"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5236"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10110440"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1157"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23381"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030635"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbacli.2014.11.009"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.06.080"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.55"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14916"},{"issue":"6","key":"e_1_2_9_93_1","first-page":"5227","article-title":"miR\u2010125b\u2010mediated regulation of cell proliferation through the Jagged\u20101\/Notch signaling pathway by inhibiting BRD4 expression in psoriasis","volume":"19","author":"Pan M","year":"2019","journal-title":"Mol Med Rep"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8061901"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6643"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97426"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.07.009"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172659"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27135"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17256"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-018-0859-7"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2018.06.003"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.04.145"},{"issue":"8","key":"e_1_2_9_104_1","first-page":"461","article-title":"MiR\u201099a inhibits keratinocyte proliferation by targeting Frizzled\u20105 (FZD5) \/ FZD8 through beta\u2010catenin signaling in psoriasis","volume":"72","author":"Shen H","year":"2017","journal-title":"Pharmazie"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.08.014"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.05.005"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-018-0271-9"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.03.105"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2016.11.020"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.11.085"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.05.045"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13888"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14197"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22588"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0621-y"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.05.012"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202695"},{"issue":"2","key":"e_1_2_9_118_1","first-page":"1086","article-title":"Silencing of miR155 suppresses inflammatory responses in psoriasis through inflammasome NLRP3 regulation","volume":"42","author":"Luo Q","year":"2018","journal-title":"Int J Mol Med"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477120"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2480"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0570-4"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29685"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-018-0181-8"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.01.014"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501704200"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01066.x"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12860-019-0229-9"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0158-7"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14227"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2017_301"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-015-0259-0"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13806"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmic.2020.100016"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12253-y"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens9060463"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9424"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2009.07.006"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.271007"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.5070\/D3252042883"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nux001"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12854"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2020.110951"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.155648"},{"key":"e_1_2_9_144_1","first-page":"65","article-title":"Psoriasis and smoking: links and risks","volume":"6","author":"Naldi L","year":"2016","journal-title":"Psoriasis (Auckl)"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.116.001506"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200505-725OC"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr400998n"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2010.12.008"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-014-0790-9"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11020149"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23681.x"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.120531"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3MA0320-363RR"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09984.x"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.8.1974"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.159"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.03.035"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.07.049"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.175"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.02.972"},{"key":"e_1_2_9_161_1","first-page":"202","article-title":"Inhibition of DNA methylation by 5\u2010azacytidine","volume":"84","author":"Jones PA","year":"1983","journal-title":"Recent Results Cancer Res"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13745"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.200"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142081"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15149"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.05.040"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15504"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14332","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14332","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T02:04:25Z","timestamp":1693361065000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,5]]},"references-count":166,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/exd.14332"],"URL":"https:\/\/doi.org\/10.1111\/exd.14332","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,5]]},"assertion":[{"value":"2020-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}