{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:10:55Z","timestamp":1790867455108,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006434","name":"Consejo de Desarrollo Cient\u00edfico y Human\u00edstico, Universidad Central de Venezuela","doi-asserted-by":"publisher","award":["PG\u201009\u20108736\u20102013"],"award-info":[{"award-number":["PG\u201009\u20108736\u20102013"]}],"id":[{"id":"10.13039\/501100006434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Innate lymphoid cells (ILCs) are classified by the expression of specific transcription factors: ILC1 depending on T\u2010bet for IFN\u2010\u03b3 production; ILC2 depending on GATA3 for IL\u20105 and IL\u201013; and ILC3 depending on ROR\u2010\u03b3\u03c4 and AHR for IL\u201017 and IL\u201022. This study aimed to determine circulating ILCs in 23 patients with localized (LCL)\u00a0=\u00a07, mucocutaneous (MCL)\u00a0=\u00a010, intermediate (ICL)\u00a0=\u00a03 and diffuse (DCL)\u00a0=\u00a03 cutaneous leishmaniasis and 17 healthy controls from endemic area (EC)\u00a0=\u00a09 and non\u2010endemic area (HC)\u00a0=\u00a08. Results evidenced a higher proportion of ILC1 in LCL than controls and MCL. ILC2 was higher in DCL compared with controls. ILC3\u00a0s were abundant in MCL and DCL concerning controls. A prevalence ratio was calculated to approach cell plasticity: in LCL, the ratio showed a prevalence of ILC1\/ILC3 (plasticity 1), in contrast to DCL, and controls, where ILC2\/ILC3 (plasticity 3) is prevalent. Also, MCL and ICL showed higher ILC1\/ILC2 (plasticity 2). These results suggest that ILC1 and ILC3 in LCL are associated with disease control and regulation of inflammation, while MCL and ICL are related to immunopathology and uncontrolled inflammation. In DCL, ILC2 is associated with the tolerogenic state of these patients.<\/jats:p>","DOI":"10.1111\/exd.14351","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T22:59:10Z","timestamp":1618354750000},"page":"982-987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Innate lymphoid cells in peripheral blood of patients with American Cutaneous Leishmaniasis"],"prefix":"10.1111","volume":"30","author":[{"given":"Orqu\u00eddea L.","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Instituto de Biomedicina Ministerio para la Salud Universidad Central de Venezuela Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis A.","family":"Lugo","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina Ministerio para la Salud Universidad Central de Venezuela Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maira","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina Ministerio para la Salud Universidad Central de Venezuela Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn A.","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina Ministerio para la Salud Universidad Central de Venezuela Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Zerpa","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina Ministerio para la Salud Universidad Central de Venezuela Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7625-7713","authenticated-orcid":false,"given":"Felix J.","family":"Tapia","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina Ministerio para la Salud Universidad Central de Venezuela Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12436"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3365"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.05.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.06.019"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151750"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12639"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02023-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.12.1018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3489"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12516"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12502"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12442"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12450"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12429"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb05931.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2002.110104.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470720035.ch9"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(93)90030-T"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0282-9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.06.011"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2002.66.273"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01206.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9765238"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11813"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.028"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082683"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134698"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.406"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.5.1969"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01991.x"},{"issue":"3","key":"e_1_2_9_32_1","first-page":"30","article-title":"Diffuse Cutaneous Leishmaniasis in Venezuela","volume":"7979","author":"Zerpa O","year":"2009","journal-title":"Bahia"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08949"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101712"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.146"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1540-2"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T16:14:28Z","timestamp":1693325668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,13]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/exd.14351"],"URL":"https:\/\/doi.org\/10.1111\/exd.14351","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,13]]},"assertion":[{"value":"2020-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}