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However, its specific treatment mechanism still remains unclear. In the present study, we investigated the potential mechanism of how ALA\u2010PDT regulated intense inflammatory response in acne vulgaris. It appeared that ALA\u2010PDT suppresses proliferation and lipid secretion of primary human sebocytes. Besides, ALA\u2010PDT could up\u2010regulate the expression of CXCL8 in vivo and in vitro, amplifying the inflammatory response by recruiting T cells, B cells, neutrophils and macrophages. We also found that ALA\u2010PDT elevated the expression of CXCL8 via p38 pathway. SB203580, a p38 pathway inhibitor, decreased the expression of CXCL8 in sebocytes after ALA\u2010PDT. These findings indicate that ALA\u2010PDT amplifies the intense inflammatory response in the treatment of acne vulgaris via CXCL8. Our data decipher the mechanism of intense inflammatory response after ALA\u2010PDT for acne vulgaris.<\/jats:p>","DOI":"10.1111\/exd.14357","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T20:38:04Z","timestamp":1618605484000},"page":"923-931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["5\u2010Aminolaevulinic acid photodynamic therapy amplifies intense inflammatory response in the treatment of acne vulgaris via CXCL8"],"prefix":"10.1111","volume":"30","author":[{"given":"Linglin","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Photomedicine Shanghai Skin Disease Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Photomedicine Shanghai Skin Disease Hospital Tongji University School of 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