{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:06:39Z","timestamp":1788303999206,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T00:00:00Z","timestamp":1620518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007688","name":"American University of Beirut","doi-asserted-by":"publisher","award":["MPP 320141"],"award-info":[{"award-number":["MPP 320141"]}],"id":[{"id":"10.13039\/100007688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007688","name":"American University of Beirut","doi-asserted-by":"publisher","award":["URB 23272"],"award-info":[{"award-number":["URB 23272"]}],"id":[{"id":"10.13039\/100007688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neutrophil extracellular traps (NETs) are implicated in the pathogenesis of multiple inflammatory dermatoses. However, characterization of NETs in neutrophilic dermatoses was performed on very limited number of patients; this limitation precluded definitive conclusions. In this case series of 57 patients, we compared the amounts of neutrophils producing NETs in cutaneous lesions of different entities of neutrophilic dermatoses (17 with pyoderma gangrenosum, 37 with Sweet's syndrome and three with subcorneal pustular dermatosis). NETs were identified by double immunofluorescence on formalin\u2010fixed paraffin\u2010embedded skin biopsies using antibodies against elastase and citrullinated histone 3. Percentages of neutrophils showing NETs were high across all three entities (62.9% in PG, 48.5% in SS and 37.8% in subcorneal pustular dermatosis). The differences in mean percentages were significant between entities, with PG showing significantly superior percentage of NETs compared with SS. In our series, 15.8% of neutrophilic dermatoses were associated with malignancies, 10.5% with autoimmune diseases and 73.7% were idiopathic. Percentages of NETs were not statistically different between aetiologies. These findings suggest that NETs are abundantly produced in the various entities and different aetiologies of neutrophilic dermatoses. In comparison with SS, the superior percentage of NETs in PG is clinically mirrored in its greater ulceronecrotic nature.<\/jats:p>","DOI":"10.1111\/exd.14360","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T05:24:46Z","timestamp":1620624286000},"page":"988-994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Characterizing the presence of neutrophil extracellular traps in neutrophilic dermatoses"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9355-2474","authenticated-orcid":false,"given":"Edward","family":"Eid","sequence":"first","affiliation":[{"name":"Department of Dermatology American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Safi","sequence":"additional","affiliation":[{"name":"Department of Dermatology American University of Beirut Medical Center Beirut Lebanon"},{"name":"Department of Anatomy, Cell Biology and Physiological Science American University of Beirut Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"El Hasbani","sequence":"additional","affiliation":[{"name":"Department of Dermatology American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Aftimos","sequence":"additional","affiliation":[{"name":"National Institute of Pathology Faculty of Medicine Lebanese University, Rafic Hariri Campus Baabda Lebanon"},{"name":"Notre Dame de Secours University Hospital Byblos Lebanon"},{"name":"Faculty of Dentistry Saint Joseph University Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ossama","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Dermatology American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul\u2010Ghani","family":"Kibbi","sequence":"additional","affiliation":[{"name":"Department of Dermatology American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6780-0721","authenticated-orcid":false,"given":"Dany","family":"Nassar","sequence":"additional","affiliation":[{"name":"Department of Dermatology American University of Beirut Medical Center Beirut Lebanon"},{"name":"Department of Anatomy, Cell Biology and Physiological Science American University of Beirut Beirut Lebanon"},{"name":"D\u00e9partement de Dermatologie H\u00f4pital Cochin Tarnier Universit\u00e9 Paris Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001201"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1959"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001180"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201719"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2018.08.010"},{"issue":"17","key":"e_1_2_9_8_1","first-page":"adv00281","article-title":"Neutrophil extracellular traps are present in immune\u2010complex\u2010mediated cutaneous small vessel vasculitis and correlate with the production of reactive oxygen species and the severity of vessel damage","volume":"100","author":"Bergqvist 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