{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:50:46Z","timestamp":1771030246909,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medizinische Universit\u00e4t Wien","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is a chronic inflammatory skin disease without cure. Systemic and biological therapies are the most effective treatments for patients with severe psoriasis. However, these drugs can cause serious side effects from extended use. Safe and effective topical drugs are needed to decrease psoriatic plaques and reduce the risk of adverse effects. Amygdalin analogues are stable small molecules that showed benefits in psoriasis xenografts to immune\u2010deficient mice by systemic application. However, whether topical application of these amygdalin analogues could reduce the progression of the psoriatic phenotype in an immune\u2010competent organism is unknown. Here, we analyse the efficiency of topical application of an amygdalin analogue cream on a well\u2010established genetic and immune\u2010competent mouse model of psoriasis. Topical application of an amygdalin analogue cream ameliorates psoriasis\u2010like disease in mice, reduces epidermal hyperplasia and skin inflammation. Amygdalin analogue treatment leads to reduced expression of local pro\u2010inflammatory cytokines, but systemic pro\u2010inflammatory cytokines that are highly expressed in psoriasis patients such as IL\u201017A, IL6 or G\u2010CSF are also decreased. Furthermore, expression of important mediators of psoriasis initiation and epidermal hyperplasia, such as TNFa, S100A9 and TSLP, is decreased in lesional epidermis after amygdalin analogue treatment. In conclusion, we show that amygdalin analogue reduces the proliferative capacity of psoriasis\u2010like stimulated keratinocytes and their inflammatory response <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. These results suggest that topical application of amygdalin analogues may represent a safe and effective treatment for psoriasis.<\/jats:p>","DOI":"10.1111\/exd.14390","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T10:08:34Z","timestamp":1621246114000},"page":"1662-1674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Topical application of an amygdalin analogue reduces inflammation and keratinocyte proliferation in a psoriasis mouse model"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-7467","authenticated-orcid":false,"given":"Nuria","family":"Gago\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Genes, Development and Disease group Cancer Cell Biology Programme Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO  Madrid Spain"},{"name":"Melanoma group Molecular Oncology Programme Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Lagunas Arnal","sequence":"additional","affiliation":[{"name":"Ferrer Advanced Biotherapeutics Grupo Ferrer Internacional S.A  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0748-8147","authenticated-orcid":false,"given":"Juan J.","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Universitat Politecnica de Catalunya  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7872-0196","authenticated-orcid":false,"given":"Erwin F.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Department of Laboratory Medicine Medical University of Vienna (MUW  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13854"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804595"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0256-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01549"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3646"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01595"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.04.022"},{"key":"e_1_2_9_9_1","first-page":"59","article-title":"Serum TSLP is a potential biomarker of psoriasis vulgaris activity","volume":"9","author":"El\u2010Ghareeb MI","year":"2019","journal-title":"Psoriasis (Auckl)"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201910697"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04576.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.2014.914437"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-018-0209-x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14246"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13614"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"issue":"10","key":"e_1_2_9_17_1","first-page":"1641","article-title":"Inhibitory effect of amygdalin on lipopolysaccharide\u2010inducible TNF\u2010alpha and IL\u20101beta mRNA expression and carrageenan\u2010induced rat arthritis","volume":"18","author":"Hwang HJ","year":"2008","journal-title":"J Microbiol Biotechnol"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.1559"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/306857"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.01.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(80)90504-3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.12.071"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1387(199703)3:2<85::AID-PSC84>3.0.CO;2-0"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.23.9254"},{"issue":"6","key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2340\/0001555571479483","article-title":"Peptide T a new treatment for psoriasis? 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