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A multitude of adjuvant treatments has been studied but none have demonstrated enough efficacy to gain adoption into treatment guidelines. Global attention on Cannabis\u2010Based Therapies is increasing and has been driven by quantum scientific advancements in the understanding of the endocannabinoid signalling system. Topical Cannabis\u2010Based Medicines represent a novel treatment paradigm for venous leg ulcers in terms of promoting wound closure. Fourteen complex patients with sixteen recalcitrant leg ulcers were treated with Topical Cannabis\u2010Based Medicines in conjunction with compression bandaging, every second day, to both wound bed and peri\u2010wound tissues. The cohort had a mean age of 75.8\u00a0years and was medically complex as reflected by a mean M3 multimorbidity index score of 2.94 and a mean Palliative Performance Scale score of 67.1%. Complete wound closure, defined as being fully epithelialized, was achieved among 11 patients (79%) and 13 wounds (81%) within a median of 34\u00a0days. All three remaining patients demonstrated progressive healing trends but were lost to follow\u2010up. The treatments were well tolerated, and no significant adverse reactions were experienced. The rapid wound closure of previously non\u2010healing venous leg ulcers among elderly and highly complex patients suggests that Topical Cannabis\u2010Based Medicines may become effective adjuvants in conjunction with compression therapy. This may also indicate that they may have an even broader role within integumentary and wound management. Therefore, this treatment paradigm warrants being subjected to controlled trials.<\/jats:p>","DOI":"10.1111\/exd.14395","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T01:46:30Z","timestamp":1621475190000},"page":"1258-1267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Topical cannabis\u2010based medicines \u2013 A novel adjuvant treatment for venous leg ulcers: An open\u2010label trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-0617","authenticated-orcid":false,"given":"Vincent","family":"Maida","sequence":"first","affiliation":[{"name":"Division of Palliative Care University of Toronto  Toronto ON Canada"},{"name":"Division of Supportive &amp; Palliative Care William Osler Health System  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runjie Bill","family":"Shi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Toronto  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco Gabriele Tatangelo","family":"Fazzari","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Ottawa  Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"Zomparelli","sequence":"additional","affiliation":[{"name":"McMaster University  Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"issue":"5","key":"e_1_2_9_2_1","first-page":"686","article-title":"Venous leg ulcers","volume":"2016","author":"Nelson EA","year":"2016","journal-title":"BMJ Clin Evid"},{"key":"e_1_2_9_3_1","unstructured":"GravesN ZhengH.The Prevalence and Incidence of Chronic Wounds: A Literature 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