{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T17:06:21Z","timestamp":1748019981238,"version":"3.40.5"},"reference-count":6,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis and psoriatic arthritis (PsA) are interrelated inflammatory diseases. Psoriasis usually precedes PsA onset and represents a well\u2010established risk factor for PsA development. Bone erosion is a hallmark of PsA, and the contribution of cutaneous psoriatic inflammation in this process has been demonstrated. However, little is still known on the pathogenetic mechanisms that link psoriatic skin to joint damage. Clinical features of psoriatic disease, including specific body site involvement, seem to be important risk predictors of PsA. The aim of this pilot research study was to investigate if psoriatic cutaneous inflammation, affecting these anatomical predictive sites for PsA, could be linked to osteoclast differentiation and activity. Our results showed that psoriasis skin localizations were positively related to the osteoclastogenic profile in psoriatic patients. These results provide new insights into the fascinating skin\u2010joint axis concept.<\/jats:p>","DOI":"10.1111\/exd.14424","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T09:13:39Z","timestamp":1625130819000},"page":"1834-1837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical predictors of psoriatic arthritis and osteoclast differentiation"],"prefix":"10.1111","volume":"30","author":[{"given":"Claudio","family":"Lembo","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery University of Naples Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0849-715X","authenticated-orcid":false,"given":"Annunziata","family":"Raimondo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d University of Salerno  Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amato","family":"de Paulis","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences University of Naples Federico II  Naples Italy"},{"name":"Center for Basic and Clinical Immunology Research (CISI) WAO Center of Excellence University of Naples Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Mormile","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences University of Naples Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca Wanda","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences University of Naples Federico II  Naples Italy"},{"name":"Center for Basic and Clinical Immunology Research (CISI) WAO Center of Excellence University of Naples Federico II  Naples 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