{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:04:03Z","timestamp":1792195443540,"version":"4.4.0"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reportedly, decreases in fatty acid (FA) chain length of ceramide (CER) are associated with interferon\u2010\u03b3 (IFN\u2010\u03b3), which shows increased expression in psoriasis. However, the underlying mechanism of this association remains unclear. Therefore, in this study, we aimed to clarify this association between FA chain length of CER, IFN\u2010\u03b3, and the major transcriptional factors involving psoriasis. CER profiling according to FA chain length and class was performed in murine epidermis (<jats:italic>n<\/jats:italic>\u00a0=\u00a010 BALB\/c mice topically treated with imiquimod, <jats:italic>n<\/jats:italic>\u00a0=\u00a010 controls) and human stratum corneum (SC) (<jats:italic>n<\/jats:italic>\u00a0=\u00a012 psoriasis, <jats:italic>n<\/jats:italic>\u00a0=\u00a011 controls). The expression of lipid synthetic enzymes, including elongases (ELOVLs), in murine epidermis was also measured using RT\u2010PCR. Furthermore, the association of IFN\u2010\u03b3 with various enzymes and transcription factors involved in the generation of long\u2010chain CERs was also investigated using in vitro keratinocyte. A significant decrease in the percentage of long\u2010chain CERs was observed in psoriasis\u2010like murine epidermis and human psoriatic SC. Additionally, the expression levels of <jats:italic>ELOVL1<\/jats:italic>, <jats:italic>ELOVL4<\/jats:italic>, and <jats:italic>ceramide synthase3 (CerS3)<\/jats:italic> were significantly decreased in psoriasis\u2010like murine epidermis and IFN\u2010\u03b3\u2010treated keratinocyte. There was also a significant decrease in the expression of transcriptional factors, including peroxisome proliferator\u2010activated receptor (PPAR), in IFN\u2010\u03b3 treated keratinocyte. Thus, it could be suggested that IFN\u2010\u03b3 may regulate ELOVL and CerS levels by down\u2010regulating the transcriptional factors. Additionally, given the possible involvement of PPARs or liver X receptor agonist in the CER elongation process, they may serve as potential therapeutic agents for lengthening the CER FAs in psoriasis.<\/jats:p>","DOI":"10.1111\/exd.14431","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T14:41:12Z","timestamp":1626446472000},"page":"122-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Decrease of ceramides with long\u2010chain fatty acids in psoriasis: Possible inhibitory effect of interferon gamma on chain elongation"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7133-7677","authenticated-orcid":false,"given":"Bo\u2010Kyung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Yonsei University Wonju College of Medicine Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Cheol","family":"Shon","sequence":"additional","affiliation":[{"name":"BK21 FOUR Community\u2010Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National University Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Seok","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yonsei University Wonju College of Medicine Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang\u2010Hyeon","family":"Liu","sequence":"additional","affiliation":[{"name":"BK21 FOUR Community\u2010Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National University Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2369-8216","authenticated-orcid":false,"given":"Jong Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yonsei University Wonju College of Medicine Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ku","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yonsei University Wonju College of Medicine Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Phil","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yonsei University Wonju College of Medicine Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.03.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.08.022"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.199"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.440"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.4733"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.364"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P030338"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.05.005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441540"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071\u2010200304020\u201000004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2013.08.011"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M800014-JLR200"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272\u2010016\u20100794\u20109"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00192-13"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2014.017"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2013.11.006"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(93)90135-N"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00371745"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007894200"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022\u2010202X.2005.23668.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802999"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39184-7"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010013\u20107601\u2010y"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010015\u20109239\u20104"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-017-1218-7"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43761"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13321\u2010017\u20100205\u20103"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2010.12.003"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.3.2.14662"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.333"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003536"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.153"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067317"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvs105"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.319"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.RA120000671"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2004.19.6.859"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.2336\/nishinihonhifu.72.494"},{"key":"e_1_2_8_40_1","volume-title":"Analysis of ceramide profiles in stratum corneum of atopic dermatitis and psoriasis by MALDI\u2010TOF\u2010MS","author":"Tawada C","year":"2012"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25030630"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12293"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3030268"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.517"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.10.034"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145498"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200809010-00002"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800001\u2010JLR200"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.3.3.15025"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25081832"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22976"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01414"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2016.10.001"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022\u2010202X.2004.23235.x"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2015.09.012"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022\u2010202X.2005.23838.x"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.046"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2017.12.035"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12658"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205061"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12033.x"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.5.609"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.207501"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14431","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T15:06:26Z","timestamp":1692716786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,22]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/exd.14431"],"URL":"https:\/\/doi.org\/10.1111\/exd.14431","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,22]]},"assertion":[{"value":"2021-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}