{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:06:47Z","timestamp":1792678007211,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903225"],"award-info":[{"award-number":["81903225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Seborrheic dermatitis (SD) and dandruff (DF) are common chronic inflammatory skin diseases characterized by recurrent greasy scales, sometimes with erythema and itchiness. Although the exact pathophysiology of the disease is still unclear, current theories highlight the role of microbes on the skin surface in the pathogenesis of SD. Here, we conducted a systematic review to investigate the skin microbiome alterations in patients with SD\/DF. We searched Medline\/PubMed, Embase and Web of Science for research studies published in English between 1\u00a0January 2000 and 31 December 2020. A total of 12\u00a0studies with 706 SD\/DF samples and 379\u00a0healthy samples were included in this study. The scalp and face were predominated by the fungi of Ascomycota and Basidiomycota and the bacteria of Actinobacteria and Firmicutes. In general, the included studies demonstrated an increased\n                    <jats:italic>Malassezia restricta<\/jats:italic>\n                    \/\n                    <jats:italic>Malassezia globosa<\/jats:italic>\n                    ratio and a reduction in the\n                    <jats:italic>Cutibaterium<\/jats:italic>\n                    \/\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    ratio in the setting of SD\/DF.\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    was associated with epidermal barrier damage, including elevated levels of trans\u2010epidermal water loss and pH, while\n                    <jats:italic>Cutibacterium<\/jats:italic>\n                    had a positive correlation with water content.\n                    <jats:italic>Malassezia<\/jats:italic>\n                    was also found to be related to an increased itching score and disease severity. Further studies focusing on the interactions between various microbes and the host and microbes can help us to better understand the pathogenesis of SD\/DF.\n                  <\/jats:p>","DOI":"10.1111\/exd.14450","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T08:47:19Z","timestamp":1629449239000},"page":"1546-1553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Skin microbiome alterations in seborrheic dermatitis and dandruff: A systematic review"],"prefix":"10.1111","volume":"30","author":[{"given":"Rong","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking University First Hospital Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases Beijing China"},{"name":"Research Center for Medical Mycology Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University First Hospital Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases Beijing China"},{"name":"Research Center for Medical Mycology Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1505-6528","authenticated-orcid":false,"given":"Ruojun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University First Hospital Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases Beijing China"},{"name":"Research Center for Medical Mycology Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","first-page":"1\u201022","article-title":"Seborrheic dermatitis and dandruff: a comprehensive review","volume":"3","author":"Borda LJ","year":"2015","journal-title":"J Clin Investig Dermatol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1473554"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14091"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00346"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.92"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00157"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00449-020-02333-5"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13293"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225796"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117921"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032847"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12684"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24877"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058203"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701017"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12398"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6941.2008.00629.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giy140"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15390"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-00995-7"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2008.00359.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00393"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-012-9606-z"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12688"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsyr.2005.05.006"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.10104.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.10119.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08860.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23682.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.01.001"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.12.002"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.10.023"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.0802a04"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.01.008"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200405040-00002"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2012.12.003"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2489-5"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-013-5394-8"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0232-2"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12076"},{"key":"e_1_2_10_42_1","first-page":"417","article-title":"Treatment of moderate to severe facial seborrheic dermatitis with itraconazole: an open non\u2010comparative study","volume":"10","author":"Shemer A","year":"2008","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.013"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.01.016"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq873"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14450","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T12:25:11Z","timestamp":1693311911000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,27]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/exd.14450"],"URL":"https:\/\/doi.org\/10.1111\/exd.14450","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,27]]},"assertion":[{"value":"2021-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}