{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T20:46:22Z","timestamp":1794257182215,"version":"4.9.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KA4034\u201001"],"award-info":[{"award-number":["KA4034\u201001"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1292"],"award-info":[{"award-number":["SFB 1292"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is one of the most common chronic inflammatory skin diseases and at the same time a risk factor for cardiovascular disease. Interleukin\u201017A (IL\u201017A)\u2013mediated inflammation in psoriasis may lead to vascular dysfunction. This study aimed at investigating whether anti\u2010inflammatory treatment by tumor necrosis factor (TNF)\u2010\u03b1 blockade alters vascular function in psoriasis patients. A total of 11 patients with psoriasis who underwent treatment with either adalimumab (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) or etanercept (<jats:italic>n<\/jats:italic>\u00a0=\u00a03), 10\u00a0healthy control individuals and 14 patients with coronary artery disease (CAD) were included in this study. Treatment response was assessed using the Psoriasis Area and Severity Index (PASI) score. Endothelial reactivity and resting endothelium\u2010dependent vascular tone were assessed by ultrasound measurement of flow\u2010mediated dilation (FMD) and low\u2010flow\u2013mediated constriction (l\u2010FMC), respectively. FMD was slightly impaired in psoriasis patients compared to healthy controls. Anti\u2010TNF\u2010\u03b1 treatment did not significantly change FMD levels. Psoriasis patients showed a trend towards increased baseline vascular activity compared to healthy controls. Anti\u2010TNF\u2010\u03b1 treatment significantly improved l\u2010FMC in psoriasis patients. Noteworthy, both FMD and l\u2010FMC in psoriasis patients were comparable to those in patients with CAD; however, an important influence of age differences between the groups or co\u2010existent classical cardiovascular risk factors on FMD and l\u2010FMC cannot be ruled out by our small study. The results suggest that anti\u2010inflammatory treatment with TNF\u2010\u03b1 blockade improves vascular function in patients with psoriasis, mainly by altering baseline vascular tone. Further studies will be necessary to establish the potentially protective impact of anti\u2010inflammatory therapy on vascular function in patients with chronic inflammatory diseases.<\/jats:p>","DOI":"10.1111\/exd.14452","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T18:59:21Z","timestamp":1629917961000},"page":"237-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["TNF\u2010\u03b1 blockade may lead to improvement of vascular function in psoriasis patients"],"prefix":"10.1111","volume":"31","author":[{"given":"Joanna","family":"Wegner","sequence":"first","affiliation":[{"name":"Department of Dermatology University Medical Center Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Karbach","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Cardiology 1 University Medical Center Mainz Mainz Germany"},{"name":"Center of Thrombosis and Hemostasis University Medical Center Mainz Mainz Germany"},{"name":"German Center for Cardiovascular Research (DZHK Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Drosos","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Cardiology 1 University Medical Center Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Schnorbus","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Cardiology 1 University Medical Center Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina","family":"Muxel","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Cardiology 1 University Medical Center Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Cardiology 1 University Medical Center Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Cardiology 1 University Medical Center Mainz Mainz Germany"},{"name":"Center of Thrombosis and Hemostasis University Medical Center Mainz Mainz Germany"},{"name":"German Center for Cardiovascular Research (DZHK Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Waisman","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine University Medical Center Mainz Mainzm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"M\u00fcnzel","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Cardiology 1 University Medical Center Mainz Mainz Germany"},{"name":"Center of Thrombosis and Hemostasis University Medical Center Mainz Mainz Germany"},{"name":"German Center for Cardiovascular Research (DZHK Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Gori","sequence":"additional","affiliation":[{"name":"Center of Cardiology, Cardiology 1 University Medical Center Mainz Mainz Germany"},{"name":"German Center for Cardiovascular Research (DZHK Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9802-9642","authenticated-orcid":false,"given":"Esther","family":"von Stebut","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Cologne, University Hospital Cologne and Faculty of Medicine Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03096"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp567"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.149"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-006-0703-z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.12.1493"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.321"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.87"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304108"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.10.042"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.09.021"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq412"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr361"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2011.1324"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10031.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000037521.71373.44"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14200"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199526003-00123"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz009"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.06.021"}],"container-title":["Experimental 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