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However, only a small portion of the lesions could be completely cleared by PDL treatment, which might be related to the regeneration and revascularization of the vascular structures after laser irradiation. Recently, it is believed that the suppression of regeneration and revascularization of photocoagulated blood vessels can achieve a better therapeutic outcome. We use rabbit ear and SD rat as the animal models to investigate whether PDL\u2010induced angiogenesis can be suppressed by topical metformin. Our results showed that topical application of metformin can effectively suppress the PDL\u2010induced early stage of angiogenesis via inhibition of the AKT\/mTOR\/P70S6K pathway in animal models.<\/jats:p>","DOI":"10.1111\/exd.14461","type":"journal-article","created":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T12:36:57Z","timestamp":1632659817000},"page":"393-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Topical metformin suppresses angiogenesis pathways induced by pulsed dye laser irradiation in animal models"],"prefix":"10.1111","volume":"31","author":[{"given":"Meiling","family":"Wang","sequence":"first","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lin","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhao","family":"Shi","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuechao","family":"Chen","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihao","family":"Mi","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Jia","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Pan","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Han","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1472-3563","authenticated-orcid":false,"given":"Huaxu","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1111\/bjd.15068"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1097\/DAD.0000000000000785"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1002\/lsm.20599"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1097\/DSS.0000000000001507"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1002\/lsm.20890"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1002\/lsm.21141"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1016\/j.jaad.2016.10.039"},{"key":"e_1_2_10_9_1","first-page":"6800812","article-title":"The role of laser speckle imaging in port\u2010wine stain research: recent advances and opportunities","volume":"2016","author":"Choi B","year":"2016","journal-title":"IEEE J Sel Top Quantum Electron"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1002\/lsm.22369"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.3390\/ijms20092243"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1111\/bjd.13439"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1002\/lsm.22101"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.3389\/fendo.2020.00191"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.1038\/srep43427"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.3390\/cancers11111737"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.1002\/lsm.22296"},{"key":"e_1_2_10_18_1","first-page":"1271","article-title":"Metformin triggers the intrinsic apoptotic response in human AGS gastric adenocarcinoma cells by activating AMPK and suppressing mTOR\/AKT signaling","volume":"54","author":"Lu CC","year":"2019","journal-title":"Int J Oncol"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_1","DOI":"10.1016\/j.lfs.2017.07.029"},{"doi-asserted-by":"publisher","key":"e_1_2_10_20_1","DOI":"10.12717\/DR.2020.24.2.113"},{"doi-asserted-by":"publisher","key":"e_1_2_10_21_1","DOI":"10.1371\/journal.pone.0193031"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14461","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T15:54:00Z","timestamp":1693151640000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,30]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/exd.14461"],"URL":"https:\/\/doi.org\/10.1111\/exd.14461","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"type":"print","value":"0906-6705"},{"type":"electronic","value":"1600-0625"}],"subject":[],"published":{"date-parts":[[2021,9,30]]},"assertion":[{"value":"2021-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}