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Recessive dystrophic epidermolysis bullosa (RDEB), a severe form of epidermolysis bullosa, is a rare genodermatosis that results in mechanically induced blistering of epithelial tissues that leads to chronic wounds. Currently, there is no cure for RDEB, and effective treatment is limited to protection from trauma and extensive bandaging. The care of chronic wounds and burns significantly burdens the healthcare system, further illustrating the dire need for more beneficial wound care. However, in its infancy, 3D bioprinting offers therapeutic potential for wound healing and could be a breakthrough technology for the treatment of rare, incurable genodermatoses like RDEB. This viewpoint essay outlines the promise of 3D bioprinting applications for treating RDEB, including skin regeneration, a delivery system for gene\u2010edited cells and small molecules, and disease modelling. Although the future of 3D bioprinting is encouraging, there are many technical challenges to overcome\u2013including optimizing bioink and cell source\u2013before this approach can be widely implemented in clinical practice.<\/jats:p>","DOI":"10.1111\/exd.14484","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T16:45:08Z","timestamp":1635266708000},"page":"384-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Future applications of 3D bioprinting: A promising technology for treating recessive dystrophic epidermolysis bullosa"],"prefix":"10.1111","volume":"31","author":[{"given":"Courtney M.","family":"Popp","sequence":"first","affiliation":[{"name":"Department of Pediatrics Medical School University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical School University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy R.","family":"Eide","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical School University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0957-4380","authenticated-orcid":false,"given":"Jakub","family":"Tolar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical School University of Minnesota Minneapolis Minnesota USA"},{"name":"Stem Cell Institute University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.07.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2011.06.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2008.00436.x"},{"key":"e_1_2_8_5_1","volume-title":"Wound healing","author":"Sen CK","year":"2017"},{"key":"e_1_2_8_6_1","unstructured":"SettipalliSA robust market rich with opportunities: Advanced wound dressings. 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