{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:53:22Z","timestamp":1788386002581,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To conduct a clinical biochemical study that aids in investigation of some non\u2010coding RNA expressions and polymorphisms (including long non\u2010coding RNAs and miRNAs) namely, MALAT\u20101 and miR\u20109 in attempt to provide new diagnostic biomarkers in vitiligo patients for Egyptians. Twenty patients having vitiligo and other twenty apparently controls were included in this study. Serum and biopsy were taken where patients were classified into lesional and peri\u2010lesional groups. Laboratory and pathological investigations were assessed. Serum miR\u20109 and long\u2010non coding MALAT\u20101 were measured. Vitiligo patients had a mean age of 36.40\u00b113.75. The mean serum miR\u20109 level in patients group (4.28\u00a0\u00b1\u00a01.70) was significantly higher than in the control (1.05\u00a0\u00b1\u00a00.12) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). The MALAT\u20101 level in vitiligo patients was (3.65\u00a0\u00b1\u00a01.30) significantly higher than control (1.45\u00a0\u00b1\u00a00.15) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). There was a positive association between the expression levels of MALAT\u20101and miR\u20109in serum and tissue as well where <jats:italic>p<\/jats:italic>\u2010value &lt;0.05. miR\u20109 as well as long non\u2010coding MALAT\u20101 may be considered as biomarkers for vitiligo susceptibility which may provide a new direction for treatment.<\/jats:p>","DOI":"10.1111\/exd.14487","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T13:07:05Z","timestamp":1635512825000},"page":"381-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Is there a relation between long non\u2010coding RNA MALAT\u20101 and miRNA\u20109 in Egyptian patients with Vitiligo?"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3769-5067","authenticated-orcid":false,"given":"Nesreen M. Abo","family":"Raia","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Fayoum University Fayoum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3031-3599","authenticated-orcid":false,"given":"Olfat G.","family":"Shaker","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Molecular Biology Faculty of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab M.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Fayoum University Fayoum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talal A.","family":"Abd elrahim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Fayoum University Fayoum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8166-7-S1-P118"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16500-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10071044"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6532"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13189"},{"issue":"19","key":"e_1_2_7_8_1","first-page":"1","article-title":"Long non\u2010coding RNA MALAT\u20101 contributes to cell apoptosis by sponging miR\u2010124 in Parkinson disease","volume":"7","author":"Liu W","year":"2017","journal-title":"Cell Biosci"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810909106"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0765-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep02535"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.111615"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12086"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13564"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19666"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.06.086"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19914"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14487","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.14487","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T15:53:35Z","timestamp":1693151615000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,16]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/exd.14487"],"URL":"https:\/\/doi.org\/10.1111\/exd.14487","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,16]]},"assertion":[{"value":"2021-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}