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This manifests clinically as the rapid development of cutaneous itch, erythema and wheal formation after several minutes of sun exposure. Disease mechanisms in solar urticaria remain incompletely elucidated and there have been few recent investigations of its pathobiology. Historic passive transfer experiments performed during the twentieth century provide support for a \u2018photoallergy\u2019 model of disease pathogenesis, wherein molecular alteration of a putative chromophore by solar electromagnetic radiation produces mast cell activation via an IgE\u2010dependent mechanism. However, this model does not account for several observations made during passive transfer experiments nor does it explain a range of subsequent clinical and photobiological observations made in solar urticaria patients. Furthermore, increased understanding of the molecular dynamics underpinning cutaneous mast cell responses highlights the need to reformulate our understanding of solar urticaria pathogenesis in the context of this contemporary scientific landscape. In this review, we discuss the current understanding of solar urticaria pathogenesis and, by incorporating recent scientific and clinical observations, develop new hypotheses to drive future investigation into this intriguing disorder.<\/jats:p>","DOI":"10.1111\/exd.14493","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T08:00:44Z","timestamp":1635840044000},"page":"586-593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pathogenesis of solar urticaria: Classic perspectives and emerging concepts"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-6028","authenticated-orcid":false,"given":"Sheila Mary","family":"McSweeney","sequence":"first","affiliation":[{"name":"St. John\u2019s Institute of Dermatology Guy\u2019s Hospital  London 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