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Vitamin D<jats:sub>3<\/jats:sub> deficiency can correlate with the increased incidence, severity and duration of inflammatory skin disorders. The exact mechanism on how vitamin D<jats:sub>3<\/jats:sub> influences inflammatory skin diseases still requires clarification. However, it can be associated with the disturbances in transmembrane glycoprotein\u2014LRP2\/megalin, which is implicated in vitamin D<jats:sub>3<\/jats:sub> transport to the cell, and defects in vitamin D\u2010signalling through the nuclear receptors. Therefore, by using immunohistochemistry, we analysed the expression of LRP2\/megalin, VDR, ROR\u03b1 and ROR\u03b3 in allergic contact dermatitis, lichen simplex chronicus, sarcoidosis and psoriasis in comparison with the normal skin. We observed decreased expression of LRP2\/megalin in all inflammatory lesions in comparison with the normal skin. Significant differences were also noticed in VDR, ROR\u03b1 and ROR\u03b3 levels between inflammatory lesions and normal skin. Our research indicates disturbed expression of LRP2\/megalin, VDR, ROR\u03b1 and ROR\u03b3 in inflammatory skin lesions in comparison with normal skin. Therefore, we suggest that changes in the activity of these proteins may play role in pathogenesis of inflammatory skin disorders. Furthermore, we suggest that LRP2\/megalin, VDR, ROR\u03b1 and RORy may serve as targets in therapy of these diseases.<\/jats:p>","DOI":"10.1111\/exd.14521","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T20:50:02Z","timestamp":1641588602000},"page":"781-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Disturbed expression of vitamin D and retinoic acid\u2010related orphan receptors \u03b1 and \u03b3 and of megalin in inflammatory skin diseases"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-9965","authenticated-orcid":false,"given":"Anna A.","family":"Bro\u017cyna","sequence":"first","affiliation":[{"name":"Department of Human Biology Institute of Biology Faculty of Biological and Veterinary Sciences Nicolaus Copernicus University  Toru\u0144 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