{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:08:22Z","timestamp":1786720102809,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T00:00:00Z","timestamp":1642809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030095"],"award-info":[{"award-number":["82030095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903225"],"award-info":[{"award-number":["81903225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFC0840700"],"award-info":[{"award-number":["2019YFC0840700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFC0840706"],"award-info":[{"award-number":["2019YFC0840706"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Shifts in skin microbiome are considered to be involved in the pathogenesis of psoriasis. However, data on the microbial dysbiosis of nail psoriasis are scarce. In this study, we aim to investigate and characterize the nail bacterial and fungal microbiome in patients with psoriasis. Nail samples were collected prospectively from 36 subjects with nail psoriasis, 24 psoriatic subjects without nail involvement and 32 healthy controls. Amplicon sequencing was performed to evaluate the bacterial and fungal community compositions. Significant alterations in the bacterial microbiome were found in the nail samples of psoriatic patients. The unaffected nails in psoriatic patients were associated with higher bacterial diversity, and a higher relative abundance of <jats:italic>Enhydrobacter<\/jats:italic>, whereas nail psoriasis was correlated with a decreased relative abundance of <jats:italic>Anaerococcus<\/jats:italic>. Shifts in fungal community composition were reflected by a higher proportion of <jats:italic>Malassezia<\/jats:italic> in the unaffected nails of psoriatic patients and an increased proportion of <jats:italic>Candida<\/jats:italic> in psoriatic nails. Shifts in the nail microbiome in psoriasis suggest a potential role of microbes in the development of nail psoriasis. Future researches focusing on these microorganisms may help to explain the pathogenesis of psoriasis.<\/jats:p>","DOI":"10.1111\/exd.14528","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T04:33:16Z","timestamp":1642134796000},"page":"800-806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dysbiosis of nail microbiome in patients with psoriasis"],"prefix":"10.1111","volume":"31","author":[{"given":"Shiqi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking University First Hospital  Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis of Dermatoses  Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases  Beijing China"},{"name":"Research Center for Medical Mycology Peking University  Beijing China"},{"name":"NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics  Beijing 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