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Previous studies have shown that the expression of TRPV3 is markedly upregulated in the lesional epidermis of atopic dermatitis (AD) patients suggesting a potential pathogenetic role of the ion channel in the disease. In the current study, we aimed at defining the molecular and functional expression of TRPV3 in non\u2010lesional skin of AD patients as previous studies implicated that healthy\u2010appearing skin in AD is markedly distinct from normal skin with respect to terminal differentiation and certain immune function abnormalities. By using multiple, complementary immunolabelling and RT\u2010qPCR technologies on full\u2010thickness and epidermal shave biopsy samples from AD patients (lesional, non\u2010lesional) and healthy volunteers, we provide the first evidence that the expression of TRPV3 is markedly upregulated in non\u2010lesional human AD epidermis, similar to lesional AD samples. Of further importance, by using the patch\u2010clamp method on cultured healthy and non\u2010lesional AD keratinocytes, we also show that this upregulation is functional as determined by the significantly augmented TRPV3\u2010specific ion current (induced by agonists) on cultured non\u2010lesional AD keratinocytes when compared to healthy ones.<\/jats:p>","DOI":"10.1111\/exd.14530","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T17:38:32Z","timestamp":1642441112000},"page":"807-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Transient receptor potential vanilloid 3 expression is increased in non\u2010lesional skin of atopic dermatitis patients"],"prefix":"10.1111","volume":"31","author":[{"given":"Nikolett","family":"Vasas","sequence":"first","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Debrecen  Debrecen Hungary"},{"name":"Doctoral 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