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Quantitative and qualitative secretome profiling of AD stem cells (ADSCs) from different zones of hair growth in patients with AGA were analysed. 1\u2010mm punch samples of adipose tissue associated with hair follicles, of three scalp areas (balding, non\u2010balding and transition zones) and one periumbilical sample, were used for ADCS isolation. The ADCS secretome was analysed in conditioned media using a 41plex assay. Among the thirty\u2010five signalling proteins analysed, the levels of VEGF, EGF, IL\u20106, Eotaxin, MCP\u20103, IFN\u03b3\u2010inducible protein\u201010 and MIP\u20101\u03b1 were higher in the balding zone compared with the non\u2010balding and periumbilical zones. In contrast, MCP\u20101 was the lowest in the balding zone in comparison with the other zones. The observed differences in the secretome suggest crosstalk between angiogenic and inflammatory processes underlying AGA aetiology and may prove relevant in both the diagnosis of AGA and the application of ADSC secretome for AGA treatment.<\/jats:p>","DOI":"10.1111\/exd.14548","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T17:15:59Z","timestamp":1646068559000},"page":"936-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Different levels of EGF, VEGF, IL\u20106, MCP\u20101, MCP\u20103, IP\u201010, Eotaxin and MIP\u20101\u03b1 in the adipose\u2010derived stem cell secretome in androgenetic alopecia"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3341-8660","authenticated-orcid":false,"given":"Katarina","family":"Andjelkov","sequence":"first","affiliation":[{"name":"University of Belgrade Faculty of Medicine and BelPrime Clinic  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