{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:13:58Z","timestamp":1780402438965,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With a view to reducing the impact of <jats:italic>Cutibacterium<\/jats:italic>\u00a0<jats:italic>acnes<\/jats:italic> (<jats:italic>C<\/jats:italic>.\u00a0<jats:italic>acnes<\/jats:italic>) on acne vulgaris, it now appears interesting to modify the balance between acneic and non\u2010acneic strains of <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>acnes<\/jats:italic> using moderate approach. In the present study, we identified that a G2 dendrigraft of lysine dendrimer (G2 dendrimer) was able to modify membrane fluidity and biofilm formation of a <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>acnes<\/jats:italic> acneic strain (RT5), whereas it appeared no or less active on a <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>acnes<\/jats:italic> non\u2010acneic strain (RT6). Moreover, skin <jats:italic>ex vivo<\/jats:italic> data indicated that the G2 is able to decrease inflammation (IL1\u03b1 and TLR\u20102) and improve skin desquamation after of <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>acnes<\/jats:italic> acneic strains colonization. Then, <jats:italic>in vivo<\/jats:italic> data confirmed, after <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>acnes<\/jats:italic> quantification by metagenomic analysis that the G2 cream after 28\u00a0days of treatment was able to increase the diversity of <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>acnes<\/jats:italic> strains versus placebo cream. The data also showed a modification of the balance expression between <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>acnes<\/jats:italic> phylotype IA1 and phylotype II abundances. Taken together, the results confirm the interest of using soft compounds in cosmetic product for modifying phylotype abundances and diversity of <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>acnes<\/jats:italic> strains could be a new strategy for prevent acne vulgaris outbreak.<\/jats:p>","DOI":"10.1111\/exd.14554","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T17:24:03Z","timestamp":1646155443000},"page":"1056-1064","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Polylysine dendrigraft is able to differentially impact <i>Cutibacterium acnes<\/i> strains preventing acneic skin"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5728-0926","authenticated-orcid":false,"given":"Joan","family":"Attia\u2010Vigneau","sequence":"first","affiliation":[{"name":"Lucas Meyer Cosmetics  Toulouse 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